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Immunohistochemical expression of pd-l1 in solid tumors
; Department of Pathology, Sestre milosrdnice University Hospital Center, Zagreb, Croatia
; Department of Pathology, Sestre milosrdnice University Hospital Center, Zagreb, Croatia; School of Medicine, University of Zagreb, Zagreb, Croatia
Puni tekst: engleski, pdf (142 KB)
APA 6th Edition
Radulović, P. i Krušlin, B. (2017). Immunohistochemical expression of pd-l1 in solid tumors. Libri Oncologici, 45 (2-3), 43-45. Preuzeto s https://hrcak.srce.hr/192122
MLA 8th Edition
Radulović, Petra i Božo Krušlin. "Immunohistochemical expression of pd-l1 in solid tumors." Libri Oncologici, vol. 45, br. 2-3, 2017, str. 43-45. https://hrcak.srce.hr/192122. Citirano 18.06.2018.
Chicago 17th Edition
Radulović, Petra i Božo Krušlin. "Immunohistochemical expression of pd-l1 in solid tumors." Libri Oncologici 45, br. 2-3 (2017): 43-45. https://hrcak.srce.hr/192122
Recent clinical trials have demonstrated that it is possible to induce durable remission in several tumors (non-small cell lung cancer (NSCLC), melanoma, squamous cancer of head and neck, renal cell carcinoma, Hodgkin lymphoma, colorectal cancer) by blocking the PD-1/PD-L1 (programmed death-1/programmed death-ligand 1) axis with anti-PD-1 or anti-PD-L1 antibodies and that an objective clinical response was closely associated with immunohistochemical PD-L1expression in tumor cells. Because immunohistochemistry is widely accepted and used method for PD-L1 assessment it is important to defi ne criteria for selecting patients who are candidates for immunotherapy and can benefi t from it.
PD-1/PD-L1 pathway; immunotherapy; immunohistochemistry; solid tumors
Hrčak ID: 192122
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