Medicinski vjesnik, Vol. 30 No. (3-4), 1998.
Izvorni znanstveni članak
The peritoneal membrane function and aging
Marko Jakić
Dubravka Mihaljević
Jasminka Milas
Jerko Barbić
Marijana Jakić
Sažetak
In patients undergoing peritoneal dialysis, peritoneal membrane substitutes partially the excretory renal function. The question remains whether the function of peritoneal membrane changes significantly with age. Therefore, the authors analysed the function of peritoneal membrane (Kt/V, creatinine clearance) in 27 anuric patients, mean age 58.84±10.65 years, treated with total of 8 liters dialysate daily, during the period of 32.56±28.41 months on average. For the whole group of examines there was a significant negative correlation found between age and weekly Kt/V (r~0.627, p<0.05), but not between age and creatinine cleance (r=-0.321, NS) or age and lean body mass (r=-0.085, NS). When divided into two groups: those older than 60 (n=16), those up to 60 years of age (n=ll), no significant difference was found regarding the mean values of weekly Kt/V (1.95±0.25 : 2.08±0.36; t=1.04, NS) and weekly creatinine clearance of peritoneal membrane (59.85±6.03 : 64.07±6.35 1/1.73 m2 body surface area; t=1.73, NS). Howewer, older patients had lower creatinine excretion per kg of body weight (81.84 ±18.33 : 99.82 ±19.65 jiimol; t=2.40, p<0.05). In conclusion, no significant difference in peritoneal membrane function was found between patients older and younger than 60 years. The difference in the function of peritoneal membrane established between the two groups of peritoneal dialysis patients could not be explained as the consequence of aging solely, i.e. the influence of accompaning features of an advanced age should not be neglected.
Ključne riječi
aging; peritoneal membrane function
Hrčak ID:
192331
URI
Datum izdavanja:
1.12.1998.
Posjeta: 736 *