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Biochemia Medica, Vol. 28 No. 1, 2018.

Kratko priopćenje
https://doi.org/10.11613/BM.2018.010904

Neutrophil gelatinase-associated lipocalin and acute kidney injury in endovascular aneurysm repair or open aortic repair: a pilot study

Benedetta Rampoldi ; Laboratory Medicine Operative Unit 1 - Clinical Pathology, I.R.C.C.S. Policlinico San Donato, San Donato Milanese, Milan, Italy
Serena Tessarolo ; Laboratory Medicine Operative Unit 1 - Clinical Pathology, I.R.C.C.S. Policlinico San Donato, San Donato Milanese, Milan, Italy
Paola Giubbilini ; Laboratory Medicine Operative Unit 1 - Clinical Pathology, I.R.C.C.S. Policlinico San Donato, San Donato Milanese, Milan, Italy
Paola Gaia ; Laboratory Medicine Operative Unit 1 - Clinical Pathology, I.R.C.C.S. Policlinico San Donato, San Donato Milanese, Milan, Italy
Samantha D. Corino ; Laboratory Medicine Operative Unit 1 - Clinical Pathology, I.R.C.C.S. Policlinico San Donato, San Donato Milanese, Milan, Italy
Sarah Mazza ; Laboratory Medicine Operative Unit 1 - Clinical Pathology, I.R.C.C.S. Policlinico San Donato, San Donato Milanese, Milan, Italy
Roberta Rigolini ; Laboratory Medicine Operative Unit 1 - Clinical Pathology, I.R.C.C.S. Policlinico San Donato, San Donato Milanese, Milan, Italy
Marco Dei Poli ; Intensive Care Unit, I.R.C.C.S. Policlinico San Donato, San Donato Milanese, Milan, Italy
Elena Vianello ; Department of Biomedical Sciences for Health, Università degli Studi di Milano, Milan, Italy
Massimiliano M. Corsi Romanelli ; Laboratory Medicine Operative Unit 1 - Clinical Pathology, I.R.C.C.S. Policlinico San Donato, San Donato Milanese, Milan, Italy; Department of Biomedical Sciences for Health, Università degli Studi di Milano, Milan, Italy
Elena Costa ; Laboratory Medicine Operative Unit 1 - Clinical Pathology, I.R.C.C.S. Policlinico San Donato, San Donato Milanese, Milan, Italy

Puni tekst: engleski, pdf (1018 KB) str. 1-6 preuzimanja: 27* citiraj
APA 6th Edition
Rampoldi, B., Tessarolo, S., Giubbilini, P., Gaia, P., Corino, S.D., Mazza, S., ... Costa, E. (2018). Neutrophil gelatinase-associated lipocalin and acute kidney injury in endovascular aneurysm repair or open aortic repair: a pilot study. Biochemia Medica, 28 (1), 1-6. https://doi.org/10.11613/BM.2018.010904
MLA 8th Edition
Rampoldi, Benedetta, et al. "Neutrophil gelatinase-associated lipocalin and acute kidney injury in endovascular aneurysm repair or open aortic repair: a pilot study." Biochemia Medica, vol. 28, br. 1, 2018, str. 1-6. https://doi.org/10.11613/BM.2018.010904. Citirano 23.02.2019.
Chicago 17th Edition
Rampoldi, Benedetta, Serena Tessarolo, Paola Giubbilini, Paola Gaia, Samantha D. Corino, Sarah Mazza, Roberta Rigolini, et al. "Neutrophil gelatinase-associated lipocalin and acute kidney injury in endovascular aneurysm repair or open aortic repair: a pilot study." Biochemia Medica 28, br. 1 (2018): 1-6. https://doi.org/10.11613/BM.2018.010904
Harvard
Rampoldi, B., et al. (2018). 'Neutrophil gelatinase-associated lipocalin and acute kidney injury in endovascular aneurysm repair or open aortic repair: a pilot study', Biochemia Medica, 28(1), str. 1-6. doi: https://doi.org/10.11613/BM.2018.010904
Vancouver
Rampoldi B, Tessarolo S, Giubbilini P, Gaia P, Corino SD, Mazza S i sur. Neutrophil gelatinase-associated lipocalin and acute kidney injury in endovascular aneurysm repair or open aortic repair: a pilot study. Biochemia Medica [Internet]. 2018 [pristupljeno 23.02.2019.];28(1):1-6. doi: https://doi.org/10.11613/BM.2018.010904
IEEE
B. Rampoldi, et al., "Neutrophil gelatinase-associated lipocalin and acute kidney injury in endovascular aneurysm repair or open aortic repair: a pilot study", Biochemia Medica, vol.28, br. 1, str. 1-6, 2018. [Online]. doi: https://doi.org/10.11613/BM.2018.010904

Rad u XML formatu

Sažetak
Introduction: Acute kidney injury (AKI) occurs frequently after abdominal aortic surgery and there is currently no effective marker able to detect
early onset. The aim of this study is to evaluate the ability of neutrophil gelatinase-associated lipocalin (NGAL) to early identify the development of
acute renal damage in patients undergoing endovascular aneurysm repair (EVAR) or open aortic repair (OAR).
Materials and methods: Serial samples of blood and urine were obtained from 25 patients undergoing both EVAR and OAR. Seven male subjects
with AKI and 18 subjects with no-AKI (17 males, 1 female) were included in the study. We determined concentrations of serum creatinine (sCr) and
urinary, serum and whole blood NGAL (uNGAL, sNGAL, bNGAL) collected at baseline, and after 4 and 18 hours. AKI was defined according to the RIFLE
criteria (risk, injury, failure, loss of kidney function, and end-stage kidney disease): increase by 50% in sCr or reduction of at least 25% of estimated
glomerular filtration rate (eGFR) from baseline.
Results: Seven patients developed AKI in the stage Risk. There was no significant difference in sNGAL concentrations in the AKI group as compared
to no-AKI group. However, the uNGAL/uCreatinine ratio and bNGAL concentrations were significantly higher after 18 hours in the AKI group (no-AKI
1.69 (0.91 - 2.47) vs AKI 3.2 (2.08 - 5.92) ng/mg for uNGAL/uCreatinine ratio, P = 0.036; and no-AKI 83 (59 - 131) vs AKI 164 (126 – 263) ng/mL for
bNGAL, P = 0.029).
Conclusions: Our results suggest that uNGAL, sNGAL and bNGAL, after abdominal aortic surgery, are not suitable as early biomarkers of AKI.

Ključne riječi
Key words: acute kidney injury; neutrophil gelatinase-associated lipocalin; cardiovascular surgery; early detection; urinary biomarkers

Hrčak ID: 192378

URI
https://hrcak.srce.hr/192378

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