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METFORMIN-INDUCED LACTIC ACIDOSIS: ARE WE UP TO THE CHALLENGE OF A GROWING PROBLEM?

LUKA VIDOVIĆ   ORCID icon orcid.org/0000-0001-9673-1446 ; Department of Nephrology and Dialysis, Sestre milosrdnice University Hospital Centre, Zagreb, Croatia
DAJANA KATIČIĆ   ORCID icon orcid.org/0000-0002-3610-4560 ; Department of Nephrology and Dialysis, Sestre milosrdnice University Hospital Centre, Zagreb, Croatia
SINIŠA ŠEFER   ORCID icon orcid.org/0000-0001-6072-2492 ; Department of Nephrology and Dialysis, Sestre milosrdnice University Hospital Centre, Zagreb, Croatia

Puni tekst: hrvatski, pdf (148 KB) str. 293-301 preuzimanja: 938* citiraj
APA 6th Edition
VIDOVIĆ, L., KATIČIĆ, D. i ŠEFER, S. (2017). METFORMINOM UZROKOVANA LAKTACIDOZA: JESMO LI DORASLI IZAZOVU RASTUĆEG PROBLEMA?. Acta medica Croatica, 71 (4), 293-301. Preuzeto s https://hrcak.srce.hr/193712
MLA 8th Edition
VIDOVIĆ, LUKA, et al. "METFORMINOM UZROKOVANA LAKTACIDOZA: JESMO LI DORASLI IZAZOVU RASTUĆEG PROBLEMA?." Acta medica Croatica, vol. 71, br. 4, 2017, str. 293-301. https://hrcak.srce.hr/193712. Citirano 16.10.2019.
Chicago 17th Edition
VIDOVIĆ, LUKA, DAJANA KATIČIĆ i SINIŠA ŠEFER. "METFORMINOM UZROKOVANA LAKTACIDOZA: JESMO LI DORASLI IZAZOVU RASTUĆEG PROBLEMA?." Acta medica Croatica 71, br. 4 (2017): 293-301. https://hrcak.srce.hr/193712
Harvard
VIDOVIĆ, L., KATIČIĆ, D., i ŠEFER, S. (2017). 'METFORMINOM UZROKOVANA LAKTACIDOZA: JESMO LI DORASLI IZAZOVU RASTUĆEG PROBLEMA?', Acta medica Croatica, 71(4), str. 293-301. Preuzeto s: https://hrcak.srce.hr/193712 (Datum pristupa: 16.10.2019.)
Vancouver
VIDOVIĆ L, KATIČIĆ D, ŠEFER S. METFORMINOM UZROKOVANA LAKTACIDOZA: JESMO LI DORASLI IZAZOVU RASTUĆEG PROBLEMA?. Acta medica Croatica [Internet]. 2017 [pristupljeno 16.10.2019.];71(4):293-301. Dostupno na: https://hrcak.srce.hr/193712
IEEE
L. VIDOVIĆ, D. KATIČIĆ i S. ŠEFER, "METFORMINOM UZROKOVANA LAKTACIDOZA: JESMO LI DORASLI IZAZOVU RASTUĆEG PROBLEMA?", Acta medica Croatica, vol.71, br. 4, str. 293-301, 2017. [Online]. Dostupno na: https://hrcak.srce.hr/193712. [Citirano: 16.10.2019.]

Sažetak
Metformin-induced lactic acidosis is an uncommon, life-threatening complication occurring in patients with impaired kidney function. It develops as a result of metformin accumulation due to the inability of renal excretion and the imbalance of lactate metabolism, resulting in severe metabolic acidosis. Various studies have shown a small incidence of this complication as opposed to the large number of patients taking metformin. Provided the strict dosage measures are implemented, metformin has been shown to be a safe drug. However, any acute illness resulting in rapid kidney function deterioration can lead to this severe complication, even in patients with normal initial renal function. Based on our clinical experience in treating this severe side effect, we conclude that any severe lactic acidosis in patients with type 2 diabetes treated with metformin, with impaired renal function should be understood as metformin-induced lactic acidosis, and all available intensive care measures should be taken. Hemodialysis in its different forms (intermittent or continuous) plays a key role in the treatment, whereby it is important to appropriately select solutions that should not contain lactate. Due to the high mortality, metformin-induced lactic acidosis remains a major therapeutic problem, as well as a challenge in implementing preventive measures by family physicians and diabetologists.

Ključne riječi
metformin; adverse effects; lactic acidosis; kidney failure; treatment

Hrčak ID: 193712

URI
https://hrcak.srce.hr/193712

[hrvatski]

Posjeta: 1.039 *