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Professional paper

Margins of Safety of Intravascular Contrast Media: Body Weight, Surface Area or Toxicokinetic Approach?

Simona Bussi
Alberto Morisetti

Fulltext: english, pdf (73 KB) pages 157-160 downloads: 2.128* cite
APA 6th Edition
Bussi, S. & Morisetti, A. (2005). Margins of Safety of Intravascular Contrast Media: Body Weight, Surface Area or Toxicokinetic Approach?. Arhiv za higijenu rada i toksikologiju, 56 (2), 157-160. Retrieved from https://hrcak.srce.hr/144
MLA 8th Edition
Bussi, Simona and Alberto Morisetti. "Margins of Safety of Intravascular Contrast Media: Body Weight, Surface Area or Toxicokinetic Approach?." Arhiv za higijenu rada i toksikologiju, vol. 56, no. 2, 2005, pp. 157-160. https://hrcak.srce.hr/144. Accessed 8 Dec. 2021.
Chicago 17th Edition
Bussi, Simona and Alberto Morisetti. "Margins of Safety of Intravascular Contrast Media: Body Weight, Surface Area or Toxicokinetic Approach?." Arhiv za higijenu rada i toksikologiju 56, no. 2 (2005): 157-160. https://hrcak.srce.hr/144
Harvard
Bussi, S., and Morisetti, A. (2005). 'Margins of Safety of Intravascular Contrast Media: Body Weight, Surface Area or Toxicokinetic Approach?', Arhiv za higijenu rada i toksikologiju, 56(2), pp. 157-160. Available at: https://hrcak.srce.hr/144 (Accessed 08 December 2021)
Vancouver
Bussi S, Morisetti A. Margins of Safety of Intravascular Contrast Media: Body Weight, Surface Area or Toxicokinetic Approach?. Arh Hig Rada Toksikol. [Internet]. 2005 [cited 2021 December 08];56(2):157-160. Available from: https://hrcak.srce.hr/144
IEEE
S. Bussi and A. Morisetti, "Margins of Safety of Intravascular Contrast Media: Body Weight, Surface Area or Toxicokinetic Approach?", Arhiv za higijenu rada i toksikologiju, vol.56, no. 2, pp. 157-160, 2005. [Online]. Available: https://hrcak.srce.hr/144. [Accessed: 08 December 2021]

Abstracts
The margin of safety of a drug is defined as the ratio between toxicity in animals and safety in humans. For intravascular contrast media, the margin of safety is traditionally the ratio between LD50 and diagnostic dose, both doses being based on bodyweight. The shift to surface area dramatically reduces this margin to unacceptable values. Toxicokinetics, which relates systemic exposure associated with early toxic signs in animals to plasma level in man, seems the most accurate and predictive criterion.

Keywords
acute toxicity; diagnostic dose; LD50; toxicokinetics

Hrčak ID: 144

URI
https://hrcak.srce.hr/144

[croatian]

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