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Crystal and Molecular Structure of 3B-Hydroxy-14,15B-epoxy- 5'B,14B-card-20,22-enolide (Digirezigenin)

Alajos Kalman ; Central Research Institute for Chemistry, Hungarian Academy of Sciences, Budapest - 114, POB. 17, H-1525, Hungary
Gyula Argay ; Central Research Institute for Chemistry, Hungarian Academy of Sciences, Budapest - 114, POB. 17, H-1525, Hungary
Bela Ribar ; Institute of Physics, Faculty of Sciences, Ilije Djuriciea 4, 21000 Novi Sad, Yugoslavia
Sote Vladimirov ; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, 11000 Beograd Yugoslavia
Dobrila Živanov-Štakic ; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, 11000 Beograd Yugoslavia

Puni tekst: engleski, pdf (10 MB) str. 519-528 preuzimanja: 46* citiraj
APA 6th Edition
Kalman, A., Argay, G., Ribar, B., Vladimirov, S. i Živanov-Štakic, D. (1984). Crystal and Molecular Structure of 3B-Hydroxy-14,15B-epoxy- 5'B,14B-card-20,22-enolide (Digirezigenin). Croatica Chemica Acta, 57 (4), 519-528. Preuzeto s https://hrcak.srce.hr/194122
MLA 8th Edition
Kalman, Alajos, et al. "Crystal and Molecular Structure of 3B-Hydroxy-14,15B-epoxy- 5'B,14B-card-20,22-enolide (Digirezigenin)." Croatica Chemica Acta, vol. 57, br. 4, 1984, str. 519-528. https://hrcak.srce.hr/194122. Citirano 31.03.2020.
Chicago 17th Edition
Kalman, Alajos, Gyula Argay, Bela Ribar, Sote Vladimirov i Dobrila Živanov-Štakic. "Crystal and Molecular Structure of 3B-Hydroxy-14,15B-epoxy- 5'B,14B-card-20,22-enolide (Digirezigenin)." Croatica Chemica Acta 57, br. 4 (1984): 519-528. https://hrcak.srce.hr/194122
Harvard
Kalman, A., et al. (1984). 'Crystal and Molecular Structure of 3B-Hydroxy-14,15B-epoxy- 5'B,14B-card-20,22-enolide (Digirezigenin)', Croatica Chemica Acta, 57(4), str. 519-528. Preuzeto s: https://hrcak.srce.hr/194122 (Datum pristupa: 31.03.2020.)
Vancouver
Kalman A, Argay G, Ribar B, Vladimirov S, Živanov-Štakic D. Crystal and Molecular Structure of 3B-Hydroxy-14,15B-epoxy- 5'B,14B-card-20,22-enolide (Digirezigenin). Croatica Chemica Acta [Internet]. 1984 [pristupljeno 31.03.2020.];57(4):519-528. Dostupno na: https://hrcak.srce.hr/194122
IEEE
A. Kalman, G. Argay, B. Ribar, S. Vladimirov i D. Živanov-Štakic, "Crystal and Molecular Structure of 3B-Hydroxy-14,15B-epoxy- 5'B,14B-card-20,22-enolide (Digirezigenin)", Croatica Chemica Acta, vol.57, br. 4, str. 519-528, 1984. [Online]. Dostupno na: https://hrcak.srce.hr/194122. [Citirano: 31.03.2020.]

Sažetak
The title compound C23H3204 and its methyl-suberate ester
were discovered in Ch'an Su, the dried venom of the Chinese
toad. Its crystals are orthorhombic, space group P21212i, and quasi-
isostructural with those of the related compound digitoxigenin
(C23H340 4) . The structure was solved by direct methods and refined
by least squares technique to a conventional R index of 0.059 for
2271 unique diffractometer observations. The presence of the rigid
14, 15~-epoxy ring alters considerably the shape of ring D (17E)
relative to that in digitoxigenin (14E). However, it has little effect
upon the general features of the 14-iso-aethiocholane skeleton and
the conformation of the y-lactone ring. The amount of rotation
about the C(l 7)-C(20) bond is hardly changed while the distance
between the position of the carbonyl O relative to digitoxigenin
is only 33.2 pm. The conformation of the title compound is also
compared with that of a bufa-20, 22-dienolide (cinobufagin) which
also possesses a 14, 15~-oxirane ring.

Hrčak ID: 194122

URI
https://hrcak.srce.hr/194122

Posjeta: 76 *