hrcak mascot   Srce   HID

Izvorni znanstveni članak

The Synthesis and Angiotensin Converting Enzyme Inhibitory Activities of N-[(3-Substituted)aminocarbonyl]propanoyl-L-prolines

Vitomir Šunjić ; Department of Organic Chemistry and Biochemistry »Ruder Boskovic« Institute, 41001 Zagreb, Yugoslavia
Šumski Šimaga ; Department of Organic Chemistry and Biochemistry »Ruder Boskovic« Institute, 41001 Zagreb, Yugoslavia
Ljubinka Vitale ; Department of Organic Chemistry and Biochemistry »Ruder Boskovic« Institute, 41001 Zagreb, Yugoslavia

Puni tekst: engleski, pdf (7 MB) str. 251-264 preuzimanja: 63* citiraj
APA 6th Edition
Šunjić, V., Šimaga, Š. i Vitale, Lj. (1984). The Synthesis and Angiotensin Converting Enzyme Inhibitory Activities of N-[(3-Substituted)aminocarbonyl]propanoyl-L-prolines. Croatica Chemica Acta, 57 (2), 251-264. Preuzeto s https://hrcak.srce.hr/194162
MLA 8th Edition
Šunjić, Vitomir, et al. "The Synthesis and Angiotensin Converting Enzyme Inhibitory Activities of N-[(3-Substituted)aminocarbonyl]propanoyl-L-prolines." Croatica Chemica Acta, vol. 57, br. 2, 1984, str. 251-264. https://hrcak.srce.hr/194162. Citirano 28.02.2021.
Chicago 17th Edition
Šunjić, Vitomir, Šumski Šimaga i Ljubinka Vitale. "The Synthesis and Angiotensin Converting Enzyme Inhibitory Activities of N-[(3-Substituted)aminocarbonyl]propanoyl-L-prolines." Croatica Chemica Acta 57, br. 2 (1984): 251-264. https://hrcak.srce.hr/194162
Harvard
Šunjić, V., Šimaga, Š., i Vitale, Lj. (1984). 'The Synthesis and Angiotensin Converting Enzyme Inhibitory Activities of N-[(3-Substituted)aminocarbonyl]propanoyl-L-prolines', Croatica Chemica Acta, 57(2), str. 251-264. Preuzeto s: https://hrcak.srce.hr/194162 (Datum pristupa: 28.02.2021.)
Vancouver
Šunjić V, Šimaga Š, Vitale Lj. The Synthesis and Angiotensin Converting Enzyme Inhibitory Activities of N-[(3-Substituted)aminocarbonyl]propanoyl-L-prolines. Croatica Chemica Acta [Internet]. 1984 [pristupljeno 28.02.2021.];57(2):251-264. Dostupno na: https://hrcak.srce.hr/194162
IEEE
V. Šunjić, Š. Šimaga i Lj. Vitale, "The Synthesis and Angiotensin Converting Enzyme Inhibitory Activities of N-[(3-Substituted)aminocarbonyl]propanoyl-L-prolines", Croatica Chemica Acta, vol.57, br. 2, str. 251-264, 1984. [Online]. Dostupno na: https://hrcak.srce.hr/194162. [Citirano: 28.02.2021.]

Sažetak
Preparations of N-[3-(hetero)aryl-aminocarbonyl]propanoyl-
L-proline derivatives 12, 13, 22 and 23 are described. A novel
approach consists of fusing (80-100 °C) N-(hetero)aryl-succinimides
(7, 8, 20, 21) with unprotected L-proline and imidazole in the presence
of dimethylformamide. In vitro tests for angiotensin converting
enzyme (ACE) inhibition showed that all N-(arylaminocarbonyl)-
propanoyl-L-prolines (12, 13, 22 and 23) exhibit lower
activity than captopril (1), their IC50's ranging from 2.5 X 10-4 to
3.3 X 10-3 M.

Hrčak ID: 194162

URI
https://hrcak.srce.hr/194162

Posjeta: 125 *