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The Synthesis and Antiviral Activities of 2-Substituted azino-3-B-D-rihofuranosyl and a and B-D-arahinofuranosyl-5-carbamoylmethylenethiazolidine-4-ones

Jože Kobe ; Boris Kidric Institute of Chemistry Hajdrihova 19, 61000 Ljubljana; KRKA Pharmaceutical and Chemical Works, C. herojev 45, 68000 Novo mesto, Yugoslavia
Boris Rusjakovski ; Boris Kidric Institute of Chemistry Hajdrihova 19, 61000 Ljubljana; KRKA Pharmaceutical and Chemical Works, C. herojev 45, 68000 Novo mesto, Yugoslavia
Branko Brdar ; Central Institute for Tumours and Allied Diseases, Ilica 197, 41000 Zagreb, Yugosravia


Puni tekst: engleski pdf 4.775 Kb

str. 295-304

preuzimanja: 168

citiraj


Sažetak

2-(1-Isopropylidene and Methylbenzylidene)azino-B-n-ribofuranosyl-
5-carbamoylmethylenethiazolidine-4-one 3 were prepared
by acid catalyzed fusion of 2-(1-Isopropylidene and 1-Methylbenzylidene)
azino-5-carbamoylmethylenethiazolidine-(3H)-4-one 1, with
1-0-acetyl-2,3,5-tri-O-benzoyl-B-n-ribofuranose and from deri vative
7 through intermediates 9 and 10, subsequent ringclosure to
11 and final deprotection. a and B-arabino furanosyl derivatives
were synthesised using a direct amminolysis of protected derivative
5. All derivatives are totally inactive against herpes simplex virus,
while showing moderate activity against poliovirus 2.

Ključne riječi

Hrčak ID:

194166

URI

https://hrcak.srce.hr/194166

Datum izdavanja:

6.4.1984.

Posjeta: 474 *