Acta clinica Croatica, Vol. 56. No. 4., 2017.
Izvorni znanstveni članak
https://doi.org/10.20471/acc.2017.56.04.01
Erythropoietin in the Evaluation of Treatment Outcomes in Patients with Polytrauma
Vladimir Arsenijević
; Clinical Department of Emergency Surgery, Emergency Center, Clinical Centre of Serbia, Belgrade, Serbia
Ana Šijački
; Clinical Department of Emergency Surgery, Emergency Center, Clinical Centre of Serbia, Belgrade, Serbia; School of Medicine, University of Belgrade, Belgrade, Serbia
Ivan Marjanović
; Clinical Department of Emergency Surgery, Emergency Center, Clinical Centre of Serbia, Belgrade, Serbia
Dušan Micić
; Clinical Department of Emergency Surgery, Emergency Center, Clinical Centre of Serbia, Belgrade, Serbia
Vladimir Nikolić
; School of Medicine, University of Belgrade, Belgrade, Serbia
Aleksandar Veljković
; Faculty of Mathematics, University of Belgrade, Belgrade, Serbia
Pavle Popović
; Clinical Department of Emergency Surgery, Emergency Center, Clinical Centre of Serbia, Belgrade, Serbia
Sanja Stanković
; Center of Medical Biochemistry, Clinical Centre of Serbia, Belgrade, Serbia
Vasilije Jeremić
; Clinical Department of Emergency Surgery, Emergency Center, Clinical Centre of Serbia, Belgrade, Serbia; School of Medicine, University of Belgrade, Belgrade, Serbia
Sažetak
Polytrauma is a term describing patients with injuries involving multiple body regions that compromises function of the body and/or organ involved. The aim of the study was to evaluate the potential role of erythropoietin in predicting poorer outcome in trauma patients. This prospective study included 86 patients admitted to the Emergency Center of Serbia due to polytrauma assigned according to Injury Severity Score (ISS). The patients were further evaluated using the Acute Physiology and Chronic Health Evaluation II and Sequential Organ Failure Assessment scores and erythropoietin levels. There was a significant difference among erythropoietin levels at admission, after 48 and 72 hours, and on day 7 of hospital stay, with significantly higher levels in patients with ISS values 49-75. Based on the results, ROC curves were used to identify cut-off levels to predict ISS score with critical clinical course. It was concluded that erythropoietin could be a good marker of injury severity. Further research has to be performed to determine the cut-off values of erythropoietin that are significant for injury severity.
Ključne riječi
Multiple injuries – therapy; Erythropoietin – therapeutic use; Treatment outcome
Hrčak ID:
194963
URI
Datum izdavanja:
15.12.2017.
Posjeta: 1.572 *