Izvorni znanstveni članak
Central blood pressure and pulse wave velocity in patients with resistant hypertension
INGRID PRKAČIN
orcid.org/0000-0002-5830-7131
; Clinical Hospital Merkur, I.Zajca 19, Zagreb
PAVAO FINDRI
PETAR FEKETE
MIJA PEZIĆ
ANTONIO GOLUB
VARAHABHATLA VAMSI
orcid.org/0000-0002-9565-5696
Sažetak
Background. Te measurement of brachial
pressure (BP) has passed been on for ages,
but the central pressure detection could
only be possible with invasive techniques,
until recently non-invasive and modern
technology was introduced into the clinical
setting. Studies described that the increase
in central blood pressure (CBP) is
an indicator of future cardiovascular or
target organ damage. Compared with the
general population, cardiorenal morbidity
is much higher in patients with resistant
hypertension (RH). We investigated for
the frst time the value of CBP and pulse
wave velocity (PWV) in a group of RH patients.
Materials and Methods. Data from 80 patients
with RH (resistance to 3 or more
drugs, one is diuretic) without chronic
kidney disease, at University hospital
Merkur, Zagreb from the period of June
2017 to January 2018 were analysed. Te
pulse wave velocity (PWV), mean arterial
pressure (MAP), vessels age (older than
biological age), pulse pressure (PP), central
blood pressure (CBP), brachial pressure
(BP) were evaluated using the noninvasive
Agedio B900 device (Germany).
Results. Te median age was 58.75 (SD15.3).
27 (35%) of patients were male
(avg 53.9 y). BP and CBP were elevated
in all RH patients (53 F/27M). Te difference
between the median value of
BP (145.9/90.52mmHg, F=146.4/89.5,
M=145/92) and CBP (132.16/91.78mmHg,
F=132/90, M 131/94) was statistically signifcant
for systolic BP (p<0.01). Te mean
value of the total measured PWV value was
higher than reference for age in all RH and
was 8.84 m/s. Te mean value of PP and
MAP was higher than reference (60.11 and
123,87 mmHg). Te diference between sex
was statistically signifcant higher for PWV
in females than males (M/F= 8.1/9.2m/s,
p<0.01). Te diference between MAP median
concentration (M/F=125.83/123) and
PP (M/F=56/62mmHg) was not statistically
signifcant (p>0.01).
Conclusion. Currently no gold standard
technique is available to measure the CBP.
Future studies should address that the cuf
method could be a promising device in
every day practice for this high risk population.
Ključne riječi
resistant hypertension; central blood pressure
Hrčak ID:
195356
URI
Datum izdavanja:
1.3.2018.
Posjeta: 903 *