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Acta Pharmaceutica, Vol. 68 No. 3, 2018.

Izvorni znanstveni članak
https://doi.org/10.2478/acph-2018-0025

Dissolution rate enhancement of ketoconazole by liquisolid technique

MIR-ALI MOLAEI ; Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz 51664, Iran; Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz 51664, Iran
KARIM OSOULI-BOSTANABAD ; Center for Pharmaceutical Nanotechnology, Tabriz University of Medical Sciences, Tabriz 51664, Iran; Students Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran
KHOSRO ADIBKIA ; Center for Pharmaceutical Nanotechnology, Tabriz University of Medical Sciences, Tabriz 51664, Iran; Students Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran
JAVAD SHOKRI ; Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz 51664, Iran
SOLMAZ ASNAASHARI ; Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz 51664, Iran
YOUSEF JAVADZADEH   ORCID icon orcid.org/0000-0001-7283-3560 ; Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz 51664, Iran, Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz 51664, Iran

Puni tekst: engleski, pdf (614 KB) str. 325-336 preuzimanja: 158* citiraj
APA 6th Edition
MOLAEI, M., OSOULI-BOSTANABAD, K., ADIBKIA, K., SHOKRI, J., ASNAASHARI, S. i JAVADZADEH, Y. (2018). Dissolution rate enhancement of ketoconazole by liquisolid technique. Acta Pharmaceutica, 68 (3), 325-336. https://doi.org/10.2478/acph-2018-0025
MLA 8th Edition
MOLAEI, MIR-ALI, et al. "Dissolution rate enhancement of ketoconazole by liquisolid technique." Acta Pharmaceutica, vol. 68, br. 3, 2018, str. 325-336. https://doi.org/10.2478/acph-2018-0025. Citirano 20.02.2019.
Chicago 17th Edition
MOLAEI, MIR-ALI, KARIM OSOULI-BOSTANABAD, KHOSRO ADIBKIA, JAVAD SHOKRI, SOLMAZ ASNAASHARI i YOUSEF JAVADZADEH. "Dissolution rate enhancement of ketoconazole by liquisolid technique." Acta Pharmaceutica 68, br. 3 (2018): 325-336. https://doi.org/10.2478/acph-2018-0025
Harvard
MOLAEI, M., et al. (2018). 'Dissolution rate enhancement of ketoconazole by liquisolid technique', Acta Pharmaceutica, 68(3), str. 325-336. doi: https://doi.org/10.2478/acph-2018-0025
Vancouver
MOLAEI M, OSOULI-BOSTANABAD K, ADIBKIA K, SHOKRI J, ASNAASHARI S, JAVADZADEH Y. Dissolution rate enhancement of ketoconazole by liquisolid technique. Acta Pharm. [Internet]. 2018 [pristupljeno 20.02.2019.];68(3):325-336. doi: https://doi.org/10.2478/acph-2018-0025
IEEE
M. MOLAEI, K. OSOULI-BOSTANABAD, K. ADIBKIA, J. SHOKRI, S. ASNAASHARI i Y. JAVADZADEH, "Dissolution rate enhancement of ketoconazole by liquisolid technique", Acta Pharmaceutica, vol.68, br. 3, str. 325-336, 2018. [Online]. doi: https://doi.org/10.2478/acph-2018-0025

Sažetak
The study was conducted to enhance the dissolution rate of ketoconazole (KCZ) (a poorly water-soluble drug) using the liquisolid technique. Microcrystalline cellulose, colloidal silica, PEG400 and polyvinyl pyrrolidone (PVP) were employed as a carrier, coating substance, nonvolatile solvent and additive in the KCZ liquisolid compact formulation, respectively. The drug-to-PEG400 and carrier-to-coating ratio variations, PVP concentration and aging effects on the in vitro release behavior were assessed. Differential scanning calorimetry (DSC) and X-ray powder diffraction (XRD) data revealed no alterations in the crystalline form of the drug and the KCZ-excipient interactions within the process. The load factor and the drug release rate were significantly enhanced compared to directly compressed tablets in the presence of the additive. Increasing the PEG400-to-drug ratio in liquid medications enhanced the dissolution rate remarkably. The dissolution profile and hardness of liquisolid compacts were not significantly altered by keeping the tablets at 40 °C and relative humidity of 75 % for 6 months. With the proposed modification of the liquisolid process, it is possible to obtain flowable, compactible liquisolid powders of high-dose poorly-water soluble drugs with an enhanced dissolution rate.

Ključne riječi
ketoconazole; liquisolid; dissolution rate; Avicel; polymorphic changes

Hrčak ID: 195717

URI
https://hrcak.srce.hr/195717

Posjeta: 250 *