Izvorni znanstveni članak

https://doi.org/10.24869/psyd.2018.64

NEUROPHYSIOLOGICAL CORRELATES OF EXCITEMENT IN MEN WITH RECENT-ONSET PSYCHOSIS

Alexander Sumich ; Division of Psychology, Nottingham Trent University, Nottingham, UK; Department of Psychology, King's College London, Institute of Psychiatry, Psychology and Neuroscience, UK
Anthony Harris ; Discipline of Psychiatry, Sydney Medical School, University of Sydney, Sydney, Australia
Thomas Whitford ; The Brain Dynamics Centre, Westmead Millennium Institute, Westmead Hospital, and Westmead Clinical School, Sydney Medical School, Westmead Hospital, Sydney, Australia; School of Psychology, UNSW Australia, Sydney, NSW, 2052, Australia
Daniel Hermens ; Clinical Research Unit, Brain and Mind Research Institute, University of Sydney, Camperdown 2050, NSW, Australia
Nadja Heym ; Division of Psychology, Nottingham Trent University, Nottingham, UK
John Anderson ; Division of Psychology, Nottingham Trent University, Nottingham, UK
Claire Bloxsom ; Division of Psychology, Nottingham Trent University, Nottingham, UK
Fraenze Kibowski ; Division of Psychology, Nottingham Trent University, Nottingham, UK
Veena Kumari ; Department of Psychology, King's College London, Institute of Psychiatry, Psychology and Neuroscience, UK; Centre for Cognitive Neuroscience, College for Life Science, Brunel University London, London, UK

Sažetak

Objective: Right frontal function, as indicated by the N200 component of the event-related potential during target detection, has previously been associated with excitement (excitement, impulsivity, hostility, uncooperativeness) in men with a long-term diagnosis of schizophrenia. The current study investigated excitement in relation to N200 in men who had recently experienced their first episode of psychosis.
Subjects and methods: Twenty men who had recently suffered their first psychotic episode underwent a clinical interview and auditory oddball task.
Results: Multiple linear regression analysis showed that 58% of the variance in the excitement symptom cluster was explained by a positive association with frontal midline N200 amplitude and an inverse association with right frontal N200 amplitude. The latter was not apparent in the initial correlation, suggesting suppression by the midline activity. These associations were not explained by drug use, medication or negative symptoms. However, the correlation between excitement and midline N200 was stronger in drug users, and that between right frontal N200 and excitement was stronger in nonusers.
Conclusion: Findings support the independent contributions to excitement of mechanisms reflected in midline and right frontal N200 amplitude respectively during the early stages of psychosis.

Ključne riječi

psychosis; recent-onset; event-related potentials; N200; excitement; drug use

Hrčak ID:

195980

URI

https://hrcak.srce.hr/195980

Datum izdavanja:

16.3.2018.

Posjeta: 1.072 *