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Syntheses of the New Indole Derivatives Related to Indomethacin

M. Mihalić ; Department of Biomedical and Biochemical Research, Compagnia di Ricerca Chimica, CR C, 33048 San <;Iiovanni al Natisone (UD), Italy
V. Šunjić ; Department of Biomedical and Biochemical Research, Compagnia di Ricerca Chimica, CR C, 33048 San <;Iiovanni al Natisone (UD), Italy
F. Kajfež ; Department of Biomedical and Biochemical Research, Compagnia di Ricerca Chimica, CR C, 33048 San <;Iiovanni al Natisone (UD), Italy
V. Čaplar ; Department of Biomedical and Biochemical Research, Compagnia di Ricerca Chimica, CR C, 33048 San <;Iiovanni al Natisone (UD), Italy
T. Kovač ; Department of Biomedical and Biochemical Research, Compagnia di Ricerca Chimica, CR C, 33048 San <;Iiovanni al Natisone (UD), Italy

Puni tekst: engleski, pdf (5 MB) str. 81-92 preuzimanja: 79* citiraj
APA 6th Edition
Mihalić, M., Šunjić, V., Kajfež, F., Čaplar, V. i Kovač, T. (1978). Syntheses of the New Indole Derivatives Related to Indomethacin. Croatica Chemica Acta, 51 (1), 81-92. Preuzeto s https://hrcak.srce.hr/195983
MLA 8th Edition
Mihalić, M., et al. "Syntheses of the New Indole Derivatives Related to Indomethacin." Croatica Chemica Acta, vol. 51, br. 1, 1978, str. 81-92. https://hrcak.srce.hr/195983. Citirano 30.09.2020.
Chicago 17th Edition
Mihalić, M., V. Šunjić, F. Kajfež, V. Čaplar i T. Kovač. "Syntheses of the New Indole Derivatives Related to Indomethacin." Croatica Chemica Acta 51, br. 1 (1978): 81-92. https://hrcak.srce.hr/195983
Harvard
Mihalić, M., et al. (1978). 'Syntheses of the New Indole Derivatives Related to Indomethacin', Croatica Chemica Acta, 51(1), str. 81-92. Preuzeto s: https://hrcak.srce.hr/195983 (Datum pristupa: 30.09.2020.)
Vancouver
Mihalić M, Šunjić V, Kajfež F, Čaplar V, Kovač T. Syntheses of the New Indole Derivatives Related to Indomethacin. Croatica Chemica Acta [Internet]. 1978 [pristupljeno 30.09.2020.];51(1):81-92. Dostupno na: https://hrcak.srce.hr/195983
IEEE
M. Mihalić, V. Šunjić, F. Kajfež, V. Čaplar i T. Kovač, "Syntheses of the New Indole Derivatives Related to Indomethacin", Croatica Chemica Acta, vol.51, br. 1, str. 81-92, 1978. [Online]. Dostupno na: https://hrcak.srce.hr/195983. [Citirano: 30.09.2020.]

Sažetak
Syntheses and properties of the new indole derivatives 18-33,
being potential antiinflammatoric agents, are described. 1-p-Chlorobenzoyl-
2-methyl-3-(2'-methyl-4'-nitroimidazol-1'-yl)-5-methoxyindole
(32) have been found to possess pronounced antiinflammatoric
activity and very low ulcerogenity. Attempting preparation of
N-benzoylindole derivative 38 via sigmatropic rearrangement of the
open chain precursor 35, as a model procedure for the new synthesis
of indomethacin, very low yields on the desired cyclic product
38 have inevitably been obtained.

Hrčak ID: 195983

URI
https://hrcak.srce.hr/195983

Posjeta: 113 *