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Pregledni rad
https://doi.org/10.2478/aiht-2018-69-2966

Glutathionylation: a regulatory role of glutathione in physiological processes

Kristina Dominko ; Division of Molecular Medicine, Ruđer Bošković Institute, Zagreb, Croatia
Domagoj Đikić ; Department of Animal Physiology, Faculty of Science,University of Zagreb, Zagreb, Croatia

Puni tekst: engleski, pdf (1 MB) str. 1-24 preuzimanja: 464* citiraj
APA 6th Edition
Dominko, K. i Đikić, D. (2018). Glutathionylation: a regulatory role of glutathione in physiological processes. Arhiv za higijenu rada i toksikologiju, 69 (1), 1-24. https://doi.org/10.2478/aiht-2018-69-2966
MLA 8th Edition
Dominko, Kristina i Domagoj Đikić. "Glutathionylation: a regulatory role of glutathione in physiological processes." Arhiv za higijenu rada i toksikologiju, vol. 69, br. 1, 2018, str. 1-24. https://doi.org/10.2478/aiht-2018-69-2966. Citirano 20.09.2020.
Chicago 17th Edition
Dominko, Kristina i Domagoj Đikić. "Glutathionylation: a regulatory role of glutathione in physiological processes." Arhiv za higijenu rada i toksikologiju 69, br. 1 (2018): 1-24. https://doi.org/10.2478/aiht-2018-69-2966
Harvard
Dominko, K., i Đikić, D. (2018). 'Glutathionylation: a regulatory role of glutathione in physiological processes', Arhiv za higijenu rada i toksikologiju, 69(1), str. 1-24. https://doi.org/10.2478/aiht-2018-69-2966
Vancouver
Dominko K, Đikić D. Glutathionylation: a regulatory role of glutathione in physiological processes. Arh Hig Rada Toksikol. [Internet]. 2018 [pristupljeno 20.09.2020.];69(1):1-24. https://doi.org/10.2478/aiht-2018-69-2966
IEEE
K. Dominko i D. Đikić, "Glutathionylation: a regulatory role of glutathione in physiological processes", Arhiv za higijenu rada i toksikologiju, vol.69, br. 1, str. 1-24, 2018. [Online]. https://doi.org/10.2478/aiht-2018-69-2966

Sažetak
Glutathione (γ-glutamyl-cysteinyl-glycine) is an intracellular thiol molecule and a potent antioxidant that participates in the toxic metabolism phase II biotransformation of xenobiotics. It can bind to a variety of proteins in a process known as glutathionylation. Protein glutathionylation is now recognised as one of important posttranslational regulatory mechanisms in cell and tissue physiology. Direct and indirect regulatory roles in physiological processes include glutathionylation of major transcriptional factors, eicosanoids, cytokines, and nitric oxide (NO). This review looks into these regulatory mechanisms through examples of glutathione regulation in apoptosis, vascularisation, metabolic processes, mitochondrial integrity, immune system, and neural physiology. The focus is on the physiological roles of glutathione beyond biotransformational metabolism.

Ključne riječi
epigenetics; GSH; GSSG; immunity; transcriptional factors

Projekti
HRZZ / IP / IP-2013-11-3035 / IT-PE-FF - Primjena inovativnih tehnologija u proizvodnji biljnih ekstrakata kao sastojaka funkcionalne hrane
HRZZ / IP / IP-2014-09-9730 / ALZTAUPROTECT - Hiperfosforilacija, agregacija i transsinaptički prijenos tau proteina u Alzheimerovoj bolesti: analiza likvora i ispitivanje potencijalnih neuroprotektivnih spojeva

Hrčak ID: 196018

URI
https://hrcak.srce.hr/196018

[hrvatski]

Posjeta: 723 *