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Acta Pharmaceutica, Vol. 68 No. 3, 2018.

Kratko priopćenje
https://doi.org/10.2478/acph-2018-0029

In vivo investigation of antihyperalgesic and antinociceptive effects of peat formulations

PLAMEN IVANOV ZAGORCHEV ; Department of Biophysics, Faculty of Pharmacy, Medical University-Plovdiv, 4000 Plovdiv, Bulgaria
ELISAVETA GEORGIEVA APOSTOLOVA   ORCID icon orcid.org/0000-0002-5167-3278 ; Department of Pharmacology and Drug Toxicology, Faculty of Pharmacy, Medical University-Plovdiv, 4000 Plovdiv, Bulgaria
BISSERA ASENOVA PILICHEVA ; Technological center of emergency medicine, 4000 Plovdiv, Bulgaria
MILENA NENKOVA DRAGANOVA-FILIPOVA ; Department of Medical Biology, Medical Faculty, Medical University-Plovdiv, 4000 Plovdiv, Bulgaria; Technological center of emergency medicine, 4000 Plovdiv, Bulgaria
VESELA YULIEVA KOKOVA ; Department of Pharmacology and Drug Toxicology, Faculty of Pharmacy, Medical University-Plovdiv, 4000 Plovdiv, Bulgaria
JULIAN BORISOV LUKANOV ; Department of Biophysics, Faculty of Pharmacy, Medical University-Plovdiv, 4000 Plovdiv, Bulgaria

Puni tekst: engleski, pdf (1 MB) str. 373-380 preuzimanja: 67* citiraj
APA 6th Edition
IVANOV ZAGORCHEV, P., GEORGIEVA APOSTOLOVA, E., ASENOVA PILICHEVA, B., DRAGANOVA-FILIPOVA, M.N., YULIEVA KOKOVA, V. i BORISOV LUKANOV, J. (2018). In vivo investigation of antihyperalgesic and antinociceptive effects of peat formulations. Acta Pharmaceutica, 68 (3), 373-380. https://doi.org/10.2478/acph-2018-0029
MLA 8th Edition
IVANOV ZAGORCHEV, PLAMEN, et al. "In vivo investigation of antihyperalgesic and antinociceptive effects of peat formulations." Acta Pharmaceutica, vol. 68, br. 3, 2018, str. 373-380. https://doi.org/10.2478/acph-2018-0029. Citirano 23.02.2019.
Chicago 17th Edition
IVANOV ZAGORCHEV, PLAMEN, ELISAVETA GEORGIEVA APOSTOLOVA, BISSERA ASENOVA PILICHEVA, MILENA NENKOVA DRAGANOVA-FILIPOVA, VESELA YULIEVA KOKOVA i JULIAN BORISOV LUKANOV. "In vivo investigation of antihyperalgesic and antinociceptive effects of peat formulations." Acta Pharmaceutica 68, br. 3 (2018): 373-380. https://doi.org/10.2478/acph-2018-0029
Harvard
IVANOV ZAGORCHEV, P., et al. (2018). 'In vivo investigation of antihyperalgesic and antinociceptive effects of peat formulations', Acta Pharmaceutica, 68(3), str. 373-380. doi: https://doi.org/10.2478/acph-2018-0029
Vancouver
IVANOV ZAGORCHEV P, GEORGIEVA APOSTOLOVA E, ASENOVA PILICHEVA B, DRAGANOVA-FILIPOVA MN, YULIEVA KOKOVA V, BORISOV LUKANOV J. In vivo investigation of antihyperalgesic and antinociceptive effects of peat formulations. Acta Pharm. [Internet]. 2018 [pristupljeno 23.02.2019.];68(3):373-380. doi: https://doi.org/10.2478/acph-2018-0029
IEEE
P. IVANOV ZAGORCHEV, E. GEORGIEVA APOSTOLOVA, B. ASENOVA PILICHEVA, M.N. DRAGANOVA-FILIPOVA, V. YULIEVA KOKOVA i J. BORISOV LUKANOV, "In vivo investigation of antihyperalgesic and antinociceptive effects of peat formulations", Acta Pharmaceutica, vol.68, br. 3, str. 373-380, 2018. [Online]. doi: https://doi.org/10.2478/acph-2018-0029

Sažetak
The aim of this study is to evaluate the antihyperalgesic and antinociceptive effects of two formulations containing peat water extracts using a model of carrageenan-induced hyperalgesia, combined with a test with a mechanical stimulus, and a hot plate test. Rats were divided into seven groups (n = 6) and received local treatment with two peat formulations and two diclofenac formulations dissolved in carbopol gel and Wolff® basis creme, respectively. Carbopol gel, Wolff® basis creme and 0.9 % NaCl without tested substances were used as controls. Both peat formulations exerted an unambiguous antihyperalgesic effect 60 minutes after the treatment. In the hot plate test, the rats treated with the Wolff® basis creme peat formulation showed a tendency to prolonged latency on the first hour. The results could be explained by partial activation of peripheral α2-adrenoceptors and the possible COX-2 suppressive activity.

Ključne riječi
peat; hyperalgesia; Wistar rats

Hrčak ID: 196280

URI
https://hrcak.srce.hr/196280

Posjeta: 120 *