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Beta-hydroxytryptamines. I. Chemical Synthesis of 3-(2-Amino- 1-hydroxyethyl)indole and 5-Hydroxy-3-(2-amino-l-Hydroxy-ethyl)indole

V. Plavšić ; Institute »Ruder Boskovic«, 41000 Zagreb, Croatia, Yugoslavia
S. Kveder ; Institute »Ruder Boskovic«, 41000 Zagreb, Croatia, Yugoslavia
S. Iskrić ; Institute »Ruder Boskovic«, 41000 Zagreb, Croatia, Yugoslavia

Puni tekst: engleski, pdf (8 MB) str. 217-224 preuzimanja: 84* citiraj
APA 6th Edition
Plavšić, V., Kveder, S. i Iskrić, S. (1974). Beta-hydroxytryptamines. I. Chemical Synthesis of 3-(2-Amino- 1-hydroxyethyl)indole and 5-Hydroxy-3-(2-amino-l-Hydroxy-ethyl)indole. Croatica Chemica Acta, 46 (3), 217-224. Preuzeto s https://hrcak.srce.hr/196818
MLA 8th Edition
Plavšić, V., et al. "Beta-hydroxytryptamines. I. Chemical Synthesis of 3-(2-Amino- 1-hydroxyethyl)indole and 5-Hydroxy-3-(2-amino-l-Hydroxy-ethyl)indole." Croatica Chemica Acta, vol. 46, br. 3, 1974, str. 217-224. https://hrcak.srce.hr/196818. Citirano 25.02.2021.
Chicago 17th Edition
Plavšić, V., S. Kveder i S. Iskrić. "Beta-hydroxytryptamines. I. Chemical Synthesis of 3-(2-Amino- 1-hydroxyethyl)indole and 5-Hydroxy-3-(2-amino-l-Hydroxy-ethyl)indole." Croatica Chemica Acta 46, br. 3 (1974): 217-224. https://hrcak.srce.hr/196818
Harvard
Plavšić, V., Kveder, S., i Iskrić, S. (1974). 'Beta-hydroxytryptamines. I. Chemical Synthesis of 3-(2-Amino- 1-hydroxyethyl)indole and 5-Hydroxy-3-(2-amino-l-Hydroxy-ethyl)indole', Croatica Chemica Acta, 46(3), str. 217-224. Preuzeto s: https://hrcak.srce.hr/196818 (Datum pristupa: 25.02.2021.)
Vancouver
Plavšić V, Kveder S, Iskrić S. Beta-hydroxytryptamines. I. Chemical Synthesis of 3-(2-Amino- 1-hydroxyethyl)indole and 5-Hydroxy-3-(2-amino-l-Hydroxy-ethyl)indole. Croatica Chemica Acta [Internet]. 1974 [pristupljeno 25.02.2021.];46(3):217-224. Dostupno na: https://hrcak.srce.hr/196818
IEEE
V. Plavšić, S. Kveder i S. Iskrić, "Beta-hydroxytryptamines. I. Chemical Synthesis of 3-(2-Amino- 1-hydroxyethyl)indole and 5-Hydroxy-3-(2-amino-l-Hydroxy-ethyl)indole", Croatica Chemica Acta, vol.46, br. 3, str. 217-224, 1974. [Online]. Dostupno na: https://hrcak.srce.hr/196818. [Citirano: 25.02.2021.]

Sažetak
From indole and 5-benzyloxyindole, respectively, the corresponding
chloromethyl 3-indolyl ketones were prepared applying
Guignard reaction with chloroacetyl chloride or Vilsmeier reaction
with N,N-diethylchloroacetamide. By i. r. and n. m. r. spectroscopy
it was proved that identical compounds were obtained in both
reactions.
After the substitution of the halide with dibenzylamino group
and the reduction of the carbonyl group to hydroxyl with lithium
alumi.num hydride, benzyl groups were removed by catalytic
hydrogenation.
3-(2-Amino-1-hydroxyethy l)indole (beta-hydroxytryptamine)
and 5-hydroxy-3-(2-amino-1-hydroxyethyl)indole (beta-hydroxyserotonin)
were isolated in the form of crystalline creatinine
sulphates. Solubility and satisfying stability in aqueous solutions
make these salts suitable for biochemical and pharmaco'logical
investigations.

Hrčak ID: 196818

URI
https://hrcak.srce.hr/196818

Posjeta: 127 *