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Original scientific paper

Mechanism of Hydroxylation of Steroids. Hydroxylation of 16a-Methyl-4-pregnene-21-ol-3,20- dione Acetate with Mucor Griseo-Cyanus

U. Valcavi ; Istituto Biochimico Italiano, 20139 Milano, Italia
M. Japelj ; KRKA, Pharmaceutical and Chemical Works, 68000 Novo Mesto, Slovenia, Yugoslavia
S. Tedeschi ; Istituto Biochimico Italiano, 20139 Milano, Italia

Fulltext: english, pdf (7 MB) pages 611-617 downloads: 111* cite
APA 6th Edition
Valcavi, U., Japelj, M. & Tedeschi, S. (1973). Mechanism of Hydroxylation of Steroids. Hydroxylation of 16a-Methyl-4-pregnene-21-ol-3,20- dione Acetate with Mucor Griseo-Cyanus. Croatica Chemica Acta, 45 (4), 611-617. Retrieved from https://hrcak.srce.hr/197011
MLA 8th Edition
Valcavi, U., et al. "Mechanism of Hydroxylation of Steroids. Hydroxylation of 16a-Methyl-4-pregnene-21-ol-3,20- dione Acetate with Mucor Griseo-Cyanus." Croatica Chemica Acta, vol. 45, no. 4, 1973, pp. 611-617. https://hrcak.srce.hr/197011. Accessed 21 Apr. 2021.
Chicago 17th Edition
Valcavi, U., M. Japelj and S. Tedeschi. "Mechanism of Hydroxylation of Steroids. Hydroxylation of 16a-Methyl-4-pregnene-21-ol-3,20- dione Acetate with Mucor Griseo-Cyanus." Croatica Chemica Acta 45, no. 4 (1973): 611-617. https://hrcak.srce.hr/197011
Harvard
Valcavi, U., Japelj, M., and Tedeschi, S. (1973). 'Mechanism of Hydroxylation of Steroids. Hydroxylation of 16a-Methyl-4-pregnene-21-ol-3,20- dione Acetate with Mucor Griseo-Cyanus', Croatica Chemica Acta, 45(4), pp. 611-617. Available at: https://hrcak.srce.hr/197011 (Accessed 21 April 2021)
Vancouver
Valcavi U, Japelj M, Tedeschi S. Mechanism of Hydroxylation of Steroids. Hydroxylation of 16a-Methyl-4-pregnene-21-ol-3,20- dione Acetate with Mucor Griseo-Cyanus. Croatica Chemica Acta [Internet]. 1973 [cited 2021 April 21];45(4):611-617. Available from: https://hrcak.srce.hr/197011
IEEE
U. Valcavi, M. Japelj and S. Tedeschi, "Mechanism of Hydroxylation of Steroids. Hydroxylation of 16a-Methyl-4-pregnene-21-ol-3,20- dione Acetate with Mucor Griseo-Cyanus", Croatica Chemica Acta, vol.45, no. 4, pp. 611-617, 1973. [Online]. Available: https://hrcak.srce.hr/197011. [Accessed: 21 April 2021]

Abstracts
Mucor griseo-cyanus, which introduces an hydroxyl group in
the 14-position of several steroids, converts 16a-methyl-4-pregnene-
21-ol-3,20-dione acetate (I) into a monohydrox:yderiva1Jive for which
the structure 16a-methyl-4-pregnene-7a,21-diol-3,20-dione (III) has
been determined. 16a-Methyl-4-pregnene-21-ol-3,20-dione acetate (I) and 16a- methyl-4-pregnene-7a,21-diol-3,20-dione (III) are transformed by Mucor griseo-cyanus, with a long time of incubation, into a dihydroxyderivative for which the structure 16a-methyl-4-pregnene- 7a,12~,21-triol-3,20-dione triacetate (VI) has been determined. The, 16a-methyl group in compound I inhibits the 14n-hydroxylase of Mucor griseo-cyanus by steric hindrance.

Hrčak ID: 197011

URI
https://hrcak.srce.hr/197011

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