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https://doi.org/10.5562/cca3246

Ferrocene Bioconjugates

Mojca Čakić Semenčić ; Department of Chemistry and Biochemistry, Faculty of Food Technology and Biotechnology, University of Zagreb, Pierottijeva 6, HR-10000, Zagreb, Croatia
Lidija Barišić   ORCID icon orcid.org/0000-0003-3628-7501 ; Department of Chemistry and Biochemistry, Faculty of Food Technology and Biotechnology, University of Zagreb, Pierottijeva 6, HR-10000, Zagreb, Croatia

Puni tekst: engleski, pdf (15 MB) str. 537-569 preuzimanja: 286* citiraj
APA 6th Edition
Čakić Semenčić, M. i Barišić, L. (2017). Ferrocene Bioconjugates. Croatica Chemica Acta, 90 (4), 537-569. https://doi.org/10.5562/cca3246
MLA 8th Edition
Čakić Semenčić, Mojca i Lidija Barišić. "Ferrocene Bioconjugates." Croatica Chemica Acta, vol. 90, br. 4, 2017, str. 537-569. https://doi.org/10.5562/cca3246. Citirano 04.12.2020.
Chicago 17th Edition
Čakić Semenčić, Mojca i Lidija Barišić. "Ferrocene Bioconjugates." Croatica Chemica Acta 90, br. 4 (2017): 537-569. https://doi.org/10.5562/cca3246
Harvard
Čakić Semenčić, M., i Barišić, L. (2017). 'Ferrocene Bioconjugates', Croatica Chemica Acta, 90(4), str. 537-569. https://doi.org/10.5562/cca3246
Vancouver
Čakić Semenčić M, Barišić L. Ferrocene Bioconjugates. Croatica Chemica Acta [Internet]. 2017 [pristupljeno 04.12.2020.];90(4):537-569. https://doi.org/10.5562/cca3246
IEEE
M. Čakić Semenčić i L. Barišić, "Ferrocene Bioconjugates", Croatica Chemica Acta, vol.90, br. 4, str. 537-569, 2017. [Online]. https://doi.org/10.5562/cca3246

Sažetak
In this review we present our recent contribution to the field of bioorganometallic chemistry of ferrocene. Ferrocene conjugates with biomolecules have been synthesized and characterized using IR and NMR (1H, 13C, COSY, NOESY, HMBC) spectroscopy, ESI-MS and HRMS. The bioconjugates of ferrocene with resveratrol (2) and mannose (10, 11, 14 and 15) were biologically evaluated for their potential inhibitory effect on HepG2 cancer cells (2) and E. coli adherence to the bladder epithelium (10, 11, 14 and 15). The oxalamide-bridged ferrocene 17 was sub¬jected to conformational analysis in solution and in the solid state, and tested for its gelation and cytotoxic activity. The mono- (30–32, 36–38, 42–45) and disubstituted ferrocene conjugates with natural amino acids (21–28, 33–35, 39–41, 48, 49, 62–65, 69–72) were subjected to the detailed conformational and DFT analyses in order to determine the turn-inducing potential of ferrocene scaffolds in the corresponding peptidomimetics.

Creative Commons License This work is licensed under a Creative Commons Attribution 4.0 International License.

Ključne riječi
ferrocene; resveratrol; mannose; oxalamide; peptide; cytoxic activity; hemagglutination; gelation; conformational analysis; peptidomimetics

Hrčak ID: 197969

URI
https://hrcak.srce.hr/197969

Posjeta: 407 *