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Fluorescence In Situ Hybridisation in Detecting Chromosome Aberrations Caused by Occupational Exposure to Ionising Radiation

Davor Želježić
Vera Garaj-Vrhovac

Puni tekst: engleski, pdf (62 KB) str. 65-68 preuzimanja: 1.094* citiraj
APA 6th Edition
Želježić, D. i Garaj-Vrhovac, V. (2006). Fluorescence In Situ Hybridisation in Detecting Chromosome Aberrations Caused by Occupational Exposure to Ionising Radiation. Arhiv za higijenu rada i toksikologiju, 57 (1), 65-68. Preuzeto s https://hrcak.srce.hr/1871
MLA 8th Edition
Želježić, Davor i Vera Garaj-Vrhovac. "Fluorescence In Situ Hybridisation in Detecting Chromosome Aberrations Caused by Occupational Exposure to Ionising Radiation." Arhiv za higijenu rada i toksikologiju, vol. 57, br. 1, 2006, str. 65-68. https://hrcak.srce.hr/1871. Citirano 17.06.2019.
Chicago 17th Edition
Želježić, Davor i Vera Garaj-Vrhovac. "Fluorescence In Situ Hybridisation in Detecting Chromosome Aberrations Caused by Occupational Exposure to Ionising Radiation." Arhiv za higijenu rada i toksikologiju 57, br. 1 (2006): 65-68. https://hrcak.srce.hr/1871
Harvard
Želježić, D., i Garaj-Vrhovac, V. (2006). 'Fluorescence In Situ Hybridisation in Detecting Chromosome Aberrations Caused by Occupational Exposure to Ionising Radiation', Arhiv za higijenu rada i toksikologiju, 57(1), str. 65-68. Preuzeto s: https://hrcak.srce.hr/1871 (Datum pristupa: 17.06.2019.)
Vancouver
Želježić D, Garaj-Vrhovac V. Fluorescence In Situ Hybridisation in Detecting Chromosome Aberrations Caused by Occupational Exposure to Ionising Radiation. Arh Hig Rada Toksikol. [Internet]. 2006 [pristupljeno 17.06.2019.];57(1):65-68. Dostupno na: https://hrcak.srce.hr/1871
IEEE
D. Želježić i V. Garaj-Vrhovac, "Fluorescence In Situ Hybridisation in Detecting Chromosome Aberrations Caused by Occupational Exposure to Ionising Radiation", Arhiv za higijenu rada i toksikologiju, vol.57, br. 1, str. 65-68, 2006. [Online]. Dostupno na: https://hrcak.srce.hr/1871. [Citirano: 17.06.2019.]

Sažetak
For more than two decades, chromosome aberration analysis has been used in biomonitoring of occupational and environmental exposure to ionising radiation. Chromosome aberration analysis is a method used to detect unstable aberrations in the lymphocytes of irradiated personnel. In turn, stable chromosome aberrations that arise some time after exposure are detected using the multicolour fluorescence in situ hybridisation. This is a technique which dyes each pair of chromosomes with different colour. Due to the dynamics of unstable aberration formation, chromosome aberration analysis is more suitable for genome damage assessment of recent exposures. On the other hand, fluorescence in situ hybridisation gives information on chromosome instability caused by long-time occupational exposure to ionising radiation. Considering the high cost of fluorescence in situ hybridisation and the uncertainty of the result, it should be used in biodosimetry only when it is absolutely necessary.

Ključne riječi
biodosimetry; CA; FISH; genome damage; occupational exposure

Hrčak ID: 1871

URI
https://hrcak.srce.hr/1871

[hrvatski]

Posjeta: 1.833 *