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Pregledni rad
https://doi.org/10.5562/cca3283

Nucleofugality of Leaving Groups

Mirela Matić ; University of Zareb, Faculty of Pharmacy and Biochemistry, Ante Kovačića 1, HR-10000 Zagreb, Croatia
Bernard Denegri ; University of Zareb, Faculty of Pharmacy and Biochemistry, Ante Kovačića 1, HR-10000 Zagreb, Croatia
Sandra Jurić ; University of Zareb, Faculty of Pharmacy and Biochemistry, Ante Kovačića 1, HR-10000 Zagreb, Croatia
Olga Kronja ; University of Zareb, Faculty of Pharmacy and Biochemistry, Ante Kovačića 1, HR-10000 Zagreb, Croatia

Puni tekst: engleski, pdf (3 MB) str. 571-581 preuzimanja: 881* citiraj
APA 6th Edition
Matić, M., Denegri, B., Jurić, S. i Kronja, O. (2017). Nucleofugality of Leaving Groups. Croatica Chemica Acta, 90 (4), 571-581. https://doi.org/10.5562/cca3283
MLA 8th Edition
Matić, Mirela, et al. "Nucleofugality of Leaving Groups." Croatica Chemica Acta, vol. 90, br. 4, 2017, str. 571-581. https://doi.org/10.5562/cca3283. Citirano 04.12.2020.
Chicago 17th Edition
Matić, Mirela, Bernard Denegri, Sandra Jurić i Olga Kronja. "Nucleofugality of Leaving Groups." Croatica Chemica Acta 90, br. 4 (2017): 571-581. https://doi.org/10.5562/cca3283
Harvard
Matić, M., et al. (2017). 'Nucleofugality of Leaving Groups', Croatica Chemica Acta, 90(4), str. 571-581. https://doi.org/10.5562/cca3283
Vancouver
Matić M, Denegri B, Jurić S, Kronja O. Nucleofugality of Leaving Groups. Croatica Chemica Acta [Internet]. 2017 [pristupljeno 04.12.2020.];90(4):571-581. https://doi.org/10.5562/cca3283
IEEE
M. Matić, B. Denegri, S. Jurić i O. Kronja, "Nucleofugality of Leaving Groups", Croatica Chemica Acta, vol.90, br. 4, str. 571-581, 2017. [Online]. https://doi.org/10.5562/cca3283

Sažetak
In this short authors' review, a method for determining experimental and calculated nucleofugalities of leaving groups in a given solvents according to LFER equation log k = sf (Nf + Ef) is presented. Also, a comprehensive overview of the experimental and calculated nucleofuges specific parameters (Nf and sf) for various negatively charged and neutral leaving groups is shown. Some applications of the above method have been demonstrated: use of the electrofugalitiy and nucleofugality scales to estimate the reactivities of a variety of substrates in various solvents, as well as assessment whether a given substrate is stable in a given solvent for a sufficent amount of time, which may indicate if the substrate can be handled in the solvent of choice during synthetic and other procedures. The method can also be used to establish whether the relative reactivity of leaving groups depends on the electrofuge moiety of the substrate.

Creative Commons License This work is licensed under a Creative Commons Attribution 4.0 International License.

Ključne riječi
nucleofugality; electrofugality; leaving group; solvolysis

Hrčak ID: 198666

URI
https://hrcak.srce.hr/198666

Posjeta: 1.035 *