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Arhiv za higijenu rada i toksikologiju, Vol. 56 No. 2, 2005.

Pregledni rad

New Aspects in Classification of Carcinogens

Heidi Foth
Gisela H. Degen
Hermann M. Bolt

Puni tekst: engleski, pdf (848 KB) str. 167-175 preuzimanja: 1.803* citiraj
APA 6th Edition
Foth, H., Degen, G.H. i Bolt, H.M. (2005). New Aspects in Classification of Carcinogens. Arhiv za higijenu rada i toksikologiju, 56 (2), 167-175. Preuzeto s https://hrcak.srce.hr/146
MLA 8th Edition
Foth, Heidi, et al. "New Aspects in Classification of Carcinogens." Arhiv za higijenu rada i toksikologiju, vol. 56, br. 2, 2005, str. 167-175. https://hrcak.srce.hr/146. Citirano 17.02.2019.
Chicago 17th Edition
Foth, Heidi, Gisela H. Degen i Hermann M. Bolt. "New Aspects in Classification of Carcinogens." Arhiv za higijenu rada i toksikologiju 56, br. 2 (2005): 167-175. https://hrcak.srce.hr/146
Harvard
Foth, H., Degen, G.H., i Bolt, H.M. (2005). 'New Aspects in Classification of Carcinogens', Arhiv za higijenu rada i toksikologiju, 56(2), str. 167-175. Preuzeto s: https://hrcak.srce.hr/146 (Datum pristupa: 17.02.2019.)
Vancouver
Foth H, Degen GH, Bolt HM. New Aspects in Classification of Carcinogens. Arh Hig Rada Toksikol. [Internet]. 2005 [pristupljeno 17.02.2019.];56(2):167-175. Dostupno na: https://hrcak.srce.hr/146
IEEE
H. Foth, G.H. Degen i H.M. Bolt, "New Aspects in Classification of Carcinogens", Arhiv za higijenu rada i toksikologiju, vol.56, br. 2, str. 167-175, 2005. [Online]. Dostupno na: https://hrcak.srce.hr/146. [Citirano: 17.02.2019.]

Sažetak
The existing systems of classification of carcinogens should include a distinction between genotoxic and non-genotoxic chemicals. For non-genotoxic chemicals, permissible exposure levels can be derived at which no relevant human cancer risks are anticipated. While genotoxic carcinogens can induce chromosomal effects without mutagenic action, non-DNA-reactive genotoxins affecting topoisomerase or the spindle, or those having an exclusively aneugenic effect can be carcinogenic only at high, toxic doses. Specific mechanisms of clastogenicity and processes of carcinogenesis based on reactive oxygen have practical thresholds. Since reactive oxygen species (ROS) are generally genotoxic, the question is whether chemicals that increase ROS production will add to endogenously produced background levels and lead to nonlinear dose-effect relationships. Taking into account the presence of endogenous carcinogens, it is now becoming evident that carcinogenic risk extrapolation to low doses must be considered according to the mode of action.

Ključne riječi
carcinogenesis; chromosomal genotoxins; dose-reponse; endogenous carcinogens; genotoxicity; reactive oxygen; treshold

Hrčak ID: 146

URI
https://hrcak.srce.hr/146

[hrvatski]

Posjeta: 2.314 *