Pregledni rad

Postmenopausal Osteoporosis – Prevention and Treatment

Mirko Koršić

Sažetak

Osteoporosis is a disease of increased skeletal
fragility accompanied by low mineral density (DXA measurement
– T score below -2.5) and microarchitectural deterioration.
Fractures result from qualitative and quantitative deterioration
in the trabecular and cortical skeleton. Osteoporosis is a major
clinical problem of western civilisation. Spinal and wrist fractures
increase morbidity. However, its most serious consequence is hip
fracture, which is associated with high mortality. Osteoporosis is
also an important socioeconomic disease in Croatia. The main
objective of osteoporosis management is to prevent fractures.
Osteoporosis therapy can reduce the risk of fractures by
50%. There are several nonpharmacologic and pharmacologic
options for the prevention and treatment of the disease. On the
basis of their mechanism of action, osteoporosis drugs can be
classifi ed into two main groups. Antiresorptive agents that inhibit
osteoclasts activity are most commonly used. Osteoanabolic
agents stimulate bone formation. These drugs have substantially
improved the management of osteoporosis. As it is still not clear
whether the concomitant administration of osteoporosis drugs
in different regimens enhances the treatment effi ciency, the
combination of continuous and sequential treatment gains
considerable interest in clinical practice.

Ključne riječi

postmenopausal osteoporosis; prevention; treatment; nonpharmacologic options; pharmacotherapy

Hrčak ID:

18871

URI

https://hrcak.srce.hr/18871

Datum izdavanja:

17.10.2005.

Podaci na drugim jezicima: hrvatski

Posjeta: 4.914 *