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Kratko priopćenje
https://doi.org/10.2478/v10007-007-0050-4

Synthesis and evaluation of the biological activities of some 3-{[5-(6-methyl-4-aryl-2-oxo-1,2,3,4-tetrahydropyrimidin-5-yl)-1,3,4-oxadiazol-2-yl]-imino}-1,3-dihydro-2H-indol-2-one derivatives

SONIA GEORGE
MANOJ KUMAR PARAMESWARAN
ACHARJEE
RAJA CHAKRABORTY
THENGUNGAL KOCHUPAPPY RAVI

Puni tekst: engleski, pdf (135 KB) str. 119-129 preuzimanja: 877* citiraj
APA 6th Edition
GEORGE, S., PARAMESWARAN, M.K., ACHARJEE, CHAKRABORTY, R. i RAVI, T.K. (2008). Synthesis and evaluation of the biological activities of some 3-{[5-(6-methyl-4-aryl-2-oxo-1,2,3,4-tetrahydropyrimidin-5-yl)-1,3,4-oxadiazol-2-yl]-imino}-1,3-dihydro-2H-indol-2-one derivatives. Acta Pharmaceutica, 58 (1), 119-129. https://doi.org/10.2478/v10007-007-0050-4
MLA 8th Edition
GEORGE, SONIA, et al. "Synthesis and evaluation of the biological activities of some 3-{[5-(6-methyl-4-aryl-2-oxo-1,2,3,4-tetrahydropyrimidin-5-yl)-1,3,4-oxadiazol-2-yl]-imino}-1,3-dihydro-2H-indol-2-one derivatives." Acta Pharmaceutica, vol. 58, br. 1, 2008, str. 119-129. https://doi.org/10.2478/v10007-007-0050-4. Citirano 25.06.2019.
Chicago 17th Edition
GEORGE, SONIA, MANOJ KUMAR PARAMESWARAN, ACHARJEE, RAJA CHAKRABORTY i THENGUNGAL KOCHUPAPPY RAVI. "Synthesis and evaluation of the biological activities of some 3-{[5-(6-methyl-4-aryl-2-oxo-1,2,3,4-tetrahydropyrimidin-5-yl)-1,3,4-oxadiazol-2-yl]-imino}-1,3-dihydro-2H-indol-2-one derivatives." Acta Pharmaceutica 58, br. 1 (2008): 119-129. https://doi.org/10.2478/v10007-007-0050-4
Harvard
GEORGE, S., et al. (2008). 'Synthesis and evaluation of the biological activities of some 3-{[5-(6-methyl-4-aryl-2-oxo-1,2,3,4-tetrahydropyrimidin-5-yl)-1,3,4-oxadiazol-2-yl]-imino}-1,3-dihydro-2H-indol-2-one derivatives', Acta Pharmaceutica, 58(1), str. 119-129. doi: https://doi.org/10.2478/v10007-007-0050-4
Vancouver
GEORGE S, PARAMESWARAN MK, ACHARJEE, CHAKRABORTY R, RAVI TK. Synthesis and evaluation of the biological activities of some 3-{[5-(6-methyl-4-aryl-2-oxo-1,2,3,4-tetrahydropyrimidin-5-yl)-1,3,4-oxadiazol-2-yl]-imino}-1,3-dihydro-2H-indol-2-one derivatives. Acta Pharm. [Internet]. 2008 [pristupljeno 25.06.2019.];58(1):119-129. doi: https://doi.org/10.2478/v10007-007-0050-4
IEEE
S. GEORGE, M.K. PARAMESWARAN, ACHARJEE, R. CHAKRABORTY i T.K. RAVI, "Synthesis and evaluation of the biological activities of some 3-{[5-(6-methyl-4-aryl-2-oxo-1,2,3,4-tetrahydropyrimidin-5-yl)-1,3,4-oxadiazol-2-yl]-imino}-1,3-dihydro-2H-indol-2-one derivatives", Acta Pharmaceutica, vol.58, br. 1, str. 119-129, 2008. [Online]. doi: https://doi.org/10.2478/v10007-007-0050-4

Sažetak
Reaction of ethyl-6-methyl–2-oxo-4-aryl-1,2,3,4-tetrahydropyrimidin-5-carboxylates (1a-i) with hydrazine hydrate yielded 6-methyl-2-oxo-4-aryl-1,2,3,4-tetrahydropyrimidin-5-carbohydrazides (2a-i). These products on reaction with cyanogen bromide gave 5-(5-amino-1,3,4-oxadiazol-2-yl)-6-methyl-4-aryl-3,4-dihydropyrimidin-2(1H)-one (3a-i). The resultant aminooxadiazolylpyrimidinones were condensed with isatin to obtain various 3-{[5-(6-methyl-4-aryl-2-oxo-1,2,3,4-tetrahydropyrimidin-5-yl)-1,3,4-oxadiazol-2-yl]-imino}-1,3-dihydro-2H-indol-2-ones (4a-i). These products were characterized by IR, 1H NMR, mass spectra and elemental analysis. Products 4a-i revealed promising antibacterial, antifungal and antioxidant activity.

Ključne riječi
pyrimidinyl oxadiazole amines; pyrimidinone oxadiazolyl indolinones; antibacterial; antifungal; antioxidant

Hrčak ID: 19050

URI
https://hrcak.srce.hr/19050

[hrvatski]

Posjeta: 1.237 *