Stručni rad
Bullous pemphigoid associated with ischemic cerebrovascular accident and dementia: Exclusive blistering lesions on the upper hemiparetic limb
Sebastian Vernal
orcid.org/0000-0001-8589-0089
; Dermatology Division, Department of Medical Clinics, Ribeirão Preto Medical School, University of São Paulo, São Paulo state, Brazil.
Tamiris Julio
; Dermatology Division, Department of Medical Clinics, Ribeirão Preto Medical School, University of São Paulo, São Paulo state, Brazil.
Fernanda Cruz
; Dermatology Division, Department of Medical Clinics, Ribeirão Preto Medical School, University of São Paulo, São Paulo state, Brazil.
Norito Ishii
; Institute of Cutaneous Cell Biology, Kurume University, Kurume, Japan
Takashi Hashimoto
; Institute of Cutaneous Cell Biology, Kurume University, Kurume, Japan
Ana Maria Roselino
; Dermatology Division, Department of Medical Clinics, Ribeirão Preto Medical School, University of São Paulo, São Paulo state, Brazil.
Sažetak
Bullous pemphigoid (BP) has been associated with neurological disorders (NDs), which has led to the hypothesis that molecular mimicry exists between hemidesmosomal proteins and neuronal peptides. A 79-year-old hemiparetic woman presented with tense bullae affecting exclusively her right paretic upper limb for three months. Histopathology, taken from the perilesional area, revealed an inflammatory infiltrate with predominant eosinophils. IIF evidenced linear IgG deposition in the epidermal side of the cleavage. ELISA detected circulating anti-BP180 and anti-BP230 autoantibodies. Immunoblotting exhibited unspecific reactivity against the 190-kDa periplakin in normal human epidermal extract. The immunocompromised cutaneous district concept may explain the possible mechanism for the exclusive involvement of the autoimmune blistering disease in lymphedematous hemiparetic upper limb.
Ključne riječi
Hrčak ID:
203226
URI
Datum izdavanja:
5.7.2018.
Posjeta: 860 *