Veterinarski arhiv, Vol. 88 No. 4, 2018.
Stručni rad
https://doi.org/10.24099/vet.arhiv.0144
Intestinal adenocarcinoma in a European brown bear (Ursus arctos) - a case report
Marko Hohšteter
; Department of Veterinary Pathology, Faculty of Veterinary Medicine, University of Zagreb, Zagreb, Croatia
Ivan-Conrado Šoštarić-Zuckermann
; Department of Veterinary Pathology, Faculty of Veterinary Medicine, University of Zagreb, Zagreb, Croatia
Slaven Reljić
; Department of Biology, Faculty of Veterinary Medicine, University of Zagreb, Zagreb, Croatia
Lidija Medven Zagradišnik
; Department of Veterinary Pathology, Faculty of Veterinary Medicine, University of Zagreb, Zagreb, Croatia
Branka Artuković
; Department of Veterinary Pathology, Faculty of Veterinary Medicine, University of Zagreb, Zagreb, Croatia
Željko Grabarević
; Department of Veterinary Pathology, Faculty of Veterinary Medicine, University of Zagreb, Zagreb, Croatia
Josip Kusak
; Department of Biology, Faculty of Veterinary Medicine, University of Zagreb, Zagreb, Croatia
Đuro Huber
; Department of Biology, Faculty of Veterinary Medicine, University of Zagreb, Zagreb, Croatia
Andrea Gudan Kurilj
; Department of Veterinary Pathology, Faculty of Veterinary Medicine, University of Zagreb, Zagreb, Croatia
Sažetak
This article presents the first case of intestinal adenocarcinoma in a free living, culled 12 year old, European female brown bear (Ursus arctos), with its characteristic macropathological and histopathological manifestations. Necropsy revealed thoracic gunshot injuries (compassionate shot) and the poor physical condition of the animal, with body fat loss and musculature atrophy. An infiltrative mass protruded the jejunal wall with infiltration of the mesentery, visceral and parietal peritoneum, and distal parts of the colon and rectum. The histopathological examination presented an infiltrative, unencapsulated, moderately cellular neoplastic mass, composed of an epithelial cell population, forming irregular nests, papillary and ribbon like structures and small number of tubules, surrounded by an extensive desmoplastic reaction. Within the tumor a small number of cysts filled with mucin were noted. The epithelial neoplastic cells exhibited mild anisocytosis and anisokaryosis, and a low mitotic index. Histochemical Van Gieson staining showed strong positivity in the desmoplastic proliferation. The epithelial tumor cells were positively imunostained with cytokerain, and stromal cells with vimentin. The histological features presented are characteristic of intestinal adenocarcinomas, of the mixed tubular and mucinous type, with a prominent scirrous reaction.
Ključne riječi
intestinal adenocarcinoma; European brown bear (Ursus arctos); macropathology; histopathology; immunohistochemistry
Hrčak ID:
203993
URI
Datum izdavanja:
14.7.2018.
Posjeta: 1.139 *