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Primitive neuroectodermal tumor of the lung with pleural effusion - a case report

Veljko Flego   ORCID icon orcid.org/0000-0002-6333-9883 ; Klinički bolnički centar Rijeka, Zavod za pulmologiju
Darian Volarić   ORCID icon orcid.org/0000-0001-5702-4749 ; Dom zdravlja Primorsko-goranske županije, Rijeka
Gordana Zamolo ; Klinički bolnički centar Rijeka, Zavod za patologiju
Andrea Dekanić   ORCID icon orcid.org/0000-0003-0625-7483 ; Klinički bolnički centar Rijeka, Zavod za patologiju
Christophe Štemberger ; Klinički bolnički centar Rijeka, Zavod za kliničku citologiju
Neva Griotto   ORCID icon orcid.org/0000-0001-5445-3310 ; Klinički bolnički centar Rijeka, Klinički zavod za nuklearnu medicinu
Silvana Petretić Majnarić   ORCID icon orcid.org/0000-0002-8519-1779 ; Klinički bolnički centar Rijeka, Klinički zavod za nuklearnu medicinu
Sunčana Divošević ; Klinički bolnički centar Rijeka, Klinički zavod za nuklearnu medicinu ; Medikol
Ljiljana Bulat-Kardum ; Klinički bolnički centar Rijeka, Zavod za pulmologiju

Puni tekst: hrvatski, pdf (1 MB) str. 161-168 preuzimanja: 428* citiraj
APA 6th Edition
Flego, V., Volarić, D., Zamolo, G., Dekanić, A., Štemberger, C., Griotto, N., ... Bulat-Kardum, Lj. (2018). Primitivni neuroektodermalni tumor pluća s pleuralnim izljevom - prikaz slučaja. Medica Jadertina, 48 (3), 161-168. Preuzeto s https://hrcak.srce.hr/204758
MLA 8th Edition
Flego, Veljko, et al. "Primitivni neuroektodermalni tumor pluća s pleuralnim izljevom - prikaz slučaja." Medica Jadertina, vol. 48, br. 3, 2018, str. 161-168. https://hrcak.srce.hr/204758. Citirano 24.02.2020.
Chicago 17th Edition
Flego, Veljko, Darian Volarić, Gordana Zamolo, Andrea Dekanić, Christophe Štemberger, Neva Griotto, Silvana Petretić Majnarić, Sunčana Divošević i Ljiljana Bulat-Kardum. "Primitivni neuroektodermalni tumor pluća s pleuralnim izljevom - prikaz slučaja." Medica Jadertina 48, br. 3 (2018): 161-168. https://hrcak.srce.hr/204758
Harvard
Flego, V., et al. (2018). 'Primitivni neuroektodermalni tumor pluća s pleuralnim izljevom - prikaz slučaja', Medica Jadertina, 48(3), str. 161-168. Preuzeto s: https://hrcak.srce.hr/204758 (Datum pristupa: 24.02.2020.)
Vancouver
Flego V, Volarić D, Zamolo G, Dekanić A, Štemberger C, Griotto N i sur. Primitivni neuroektodermalni tumor pluća s pleuralnim izljevom - prikaz slučaja. Medica Jadertina [Internet]. 2018 [pristupljeno 24.02.2020.];48(3):161-168. Dostupno na: https://hrcak.srce.hr/204758
IEEE
V. Flego, et al., "Primitivni neuroektodermalni tumor pluća s pleuralnim izljevom - prikaz slučaja", Medica Jadertina, vol.48, br. 3, str. 161-168, 2018. [Online]. Dostupno na: https://hrcak.srce.hr/204758. [Citirano: 24.02.2020.]

Sažetak
Introduction: Primitive neuroectodermal tumor (PNET) is a group of rare, highly malignant neoplasms usually found in children and adolescents. The tumor tends to metastasize early, and consequently the survival rate is low.
Case report: A 29-year-old female presented with pain in the right side of the thorax and progressive breathlessness of one-month duration. Multi-slice computed tomography (MSCT) of the chest revealed a large pleural effusion in the right hemithorax, and a large expansive formation in the right upper lobe. Thoracentesis was performed, and malignant cells were found in pleural effusion. Bronchoscopic examination revealed extrinsic compression on the bronchi, without malignant cells in the samples taken. Transthoracic MSCT guided biopsy of the mass histologically revealed small cells, with hyperchromatic nuclei and atypical mitosis. Immunohistochemically, the cells were positive for CD99, NSE and CD56. Positron emission tomography (PET) CT revealed intense accumulation of 18F-fluorodeoxyglucose in the right upper lobe and in the mediastinal lymph nodes. Octreoscan showed pathological accumulation of radiopharmaceuticals in the right upper lobe and mediastinum, indicating a lesion with the expression of somatostatin receptor. The patient received chemotherapy (cisplatin and etoposide), and octreotide acetate. PET/CT showed tumor progression. Palliative radiotherapy was administered. The disease progressed rapidly and the patient died subsequently eleven months after the diagnosis.
Conclusion: PNET is an aggressive and lethal disease, therefore should be considered in the differential diagnosis of thoracic tumors regardless of the age of the patient.

Ključne riječi
primitive neuroectodermal tumor; pleural effusion; CD99; chemotherapy; malignant lung

Hrčak ID: 204758

URI
https://hrcak.srce.hr/204758

[hrvatski]

Posjeta: 644 *