Cardiologia Croatica, Vol. 13 No. 9-10, 2018.
Pregledni rad
https://doi.org/10.15836/ccar2018.263
Sex-differentiated Incidence of Autoimmune Diseases in Women and Association with Cardiovascular Risk
Asja Stipić Marković
orcid.org/0000-0003-2767-2088
; Medicinski fakultet Sveučilišta u Zagrebu, Zagreb, Hrvatska
Ana Marija Valetić
orcid.org/0000-0001-6979-2059
; Medicinski fakultet Sveučilišta u Zagrebu, Zagreb, Hrvatska; Klinički bolnički centar Sestre milosrdnice, Zagreb, Hrvatska
Ingrid Prkačin
orcid.org/0000-0002-5830-7131
; Medicinski fakultet Sveučilišta u Zagrebu, Zagreb, Hrvatska; Klinička bolnica Merkur, Zagreb, Hrvatska
Sažetak
Autoimmune diseases can cause significant and chronic morbidity and disability. Women are at a 2.7 times greater risk than men of acquiring autoimmune diseases. Cardiovascular risk in female patients with systemic lupus erythematosus and rheumatoid arthritis indicates early atherosclerosis. Patients with systemic lupus erythematosus have a 5-8 times higher incidence of coronary artery disease than the general population, which is associated with dyslipidemia, the presence of LDL-phenotype B, and simultaneously present systemic inflammation. Premature atherosclerosis in these patients is the result of traditional cardiovascular risk factors, factors specific to autoimmune disease, and inflammatory mediators. Since cardiovascular diseases are the leading cause of death, this raises the question of preventive cardiology treatment. If kidney failure develops with lupus nephritis and chronic kidney disease, the cardiovascular risk multiplies.
Ključne riječi
women; autoimmune diseases; cardiovascular risk
Hrčak ID:
204772
URI
Datum izdavanja:
3.9.2018.
Posjeta: 1.202 *