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https://doi.org/10.2478/aiht-2018-69-3125

A new approach to assessing occupational exposure to antineoplastic drugs in hospital environments

Stefano Dugheri   ORCID icon orcid.org/0000-0002-3078-7188 ; Careggi University Hospital, Medicina del Lavoro – Laboratorio di Igiene e Tossicologia Industriale1, University of Florence, Dipartimento di Medicina Sperimentale e Clinica2, Florence, Italy
Alessandro Bonari ; University of Florence, Dipartimento di Medicina Sperimentale e Clinica, Florence, Italy
Ilenia Pompilio   ORCID icon orcid.org/0000-0002-1625-2662 ; Careggi University Hospital, Medicina del Lavoro – Laboratorio di Igiene e Tossicologia Industriale, Florence, Italy
Pierpaolo Boccalon ; Careggi University Hospital, Medicina del Lavoro – Laboratorio di Igiene e Tossicologia Industriale, Florence, Italy
Nicola Mucci ; University of Florence, Dipartimento di Medicina Sperimentale e Clinica, Florence, Italy
Giulio Arcangeli ; Careggi University Hospital, Medicina del Lavoro – Laboratorio di Igiene e Tossicologia Industriale1, University of Florence, Dipartimento di Medicina Sperimentale e Clinica2, Florence, Italy

Puni tekst: engleski, pdf (1 MB) str. 226-237 preuzimanja: 164* citiraj
APA 6th Edition
Dugheri, S., Bonari, A., Pompilio, I., Boccalon, P., Mucci, N. i Arcangeli, G. (2018). A new approach to assessing occupational exposure to antineoplastic drugs in hospital environments. Arhiv za higijenu rada i toksikologiju, 69 (3), 226-237. https://doi.org/10.2478/aiht-2018-69-3125
MLA 8th Edition
Dugheri, Stefano, et al. "A new approach to assessing occupational exposure to antineoplastic drugs in hospital environments." Arhiv za higijenu rada i toksikologiju, vol. 69, br. 3, 2018, str. 226-237. https://doi.org/10.2478/aiht-2018-69-3125. Citirano 23.11.2019.
Chicago 17th Edition
Dugheri, Stefano, Alessandro Bonari, Ilenia Pompilio, Pierpaolo Boccalon, Nicola Mucci i Giulio Arcangeli. "A new approach to assessing occupational exposure to antineoplastic drugs in hospital environments." Arhiv za higijenu rada i toksikologiju 69, br. 3 (2018): 226-237. https://doi.org/10.2478/aiht-2018-69-3125
Harvard
Dugheri, S., et al. (2018). 'A new approach to assessing occupational exposure to antineoplastic drugs in hospital environments', Arhiv za higijenu rada i toksikologiju, 69(3), str. 226-237. https://doi.org/10.2478/aiht-2018-69-3125
Vancouver
Dugheri S, Bonari A, Pompilio I, Boccalon P, Mucci N, Arcangeli G. A new approach to assessing occupational exposure to antineoplastic drugs in hospital environments. Arh Hig Rada Toksikol. [Internet]. 2018 [pristupljeno 23.11.2019.];69(3):226-237. https://doi.org/10.2478/aiht-2018-69-3125
IEEE
S. Dugheri, A. Bonari, I. Pompilio, P. Boccalon, N. Mucci i G. Arcangeli, "A new approach to assessing occupational exposure to antineoplastic drugs in hospital environments", Arhiv za higijenu rada i toksikologiju, vol.69, br. 3, str. 226-237, 2018. [Online]. https://doi.org/10.2478/aiht-2018-69-3125

Sažetak
Cytotoxic antineoplastic drugs (ADs) pose occupational risk and therefore require safe handling practices. We created, optimised, and validated an innovative monitoring protocol for simultaneously assessing 21 ADs in the healthcare environment, and also proposed surface exposure levels (SELs) to facilitate the interpretation of monitoring results, as there are currently no occupational exposure limits for ADs. The environmental AD monitoring data were collected in nine Italian hospitals between 2008 and 2017 and include 74,565 measurements in 4,814 wipe samples. Excellent overall recovery and sensitivity of the analytical methods along with innovative desorption automation make this protocol useful for routine monitoring. AD contamination was found in 3,081 measurements, confirming potential exposure in healthcare workers. Samples taken at the beginning and the end of work shifts, allowed to calculate 75th and 90th percentile values for each ADs both in preparation and administration units and we created a traffic-light colour-coding system to facilitate interpretation of the findings. The introduction of SELs will provide a solid basis for improving occupational safety and focusing on contamination control.

Ključne riječi
inductively coupled plasma mass spectrometry; liquid chromatography-mass spectrometry; surface contamination; wipe test; workplace safety

Hrčak ID: 206037

URI
https://hrcak.srce.hr/206037

[hrvatski]

Posjeta: 291 *