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Chronic Recurrent Multifocal Osteomyelitis (CRMO) and Synovitis Acne Pustulosis Hyperostosis Osteitis (SAPHO) Syndrome – Two Presentations of the Same Disease?

Marija Jelušić   ORCID icon orcid.org/0000-0002-1728-4260 ; Division of clinical immunology and rheumatology Department of pediatrics University Hospital Centre Zagreb, University of Zagreb School of Medicine, Zagreb, Croatia
Nastasia Čekada ; Division of clinical immunology and rheumatology Department of pediatrics University Hospital Centre Zagreb, University of Zagreb School of Medicine, Zagreb, Croatia
Marijan Frković ; Division of clinical immunology and rheumatology Department of pediatrics University Hospital Centre Zagreb, University of Zagreb School of Medicine, Zagreb, Croatia
Kristina Potočki ; Department of Diagnostic and Interventional Radiology University Hospital Centre Zagreb, University of Zagreb School of Medicine, Zagreb, Croatia
Mihael Skerlev   ORCID icon orcid.org/0000-0003-1623-3434 ; Department of Dermatovenerology, Division of Paediatric Dermatology University Hospital Centre Zagreb, University of Zagreb School of Medicine, Zagreb, Croatia
Slobodna Murat-Sušić ; Department of Dermatovenerology, Division of Paediatric Dermatology University Hospital Centre Zagreb, University of Zagreb School of Medicine, Zagreb, Croatia
Karmela Husar ; Department of Dermatovenerology, Division of Paediatric Dermatology University Hospital Centre Zagreb, University of Zagreb School of Medicine, Zagreb, Croatia
Tomislav Đapić ; Department of Orthopedics, Division of Paediatric Orthopedics University Hospital Centre Zagreb, University of Zagreb School of Medicine, Zagreb, Croatia
Igor Šmigovec ; Department of Orthopedics, Division of Paediatric Orthopedics University Hospital Centre Zagreb, University of Zagreb School of Medicine, Zagreb, Croatia
Dubravko Bajramović ; Department of Diagnostic and Interventional Radiology University Hospital Centre Zagreb, University of Zagreb School of Medicine, Zagreb, Croatia

Puni tekst: engleski, PDF (168 KB) str. 212-212 preuzimanja: 307* citiraj
APA 6th Edition
Jelušić, M., Čekada, N., Frković, M., Potočki, K., Skerlev, M., Murat-Sušić, S., ... Bajramović, D. (2018). Chronic Recurrent Multifocal Osteomyelitis (CRMO) and Synovitis Acne Pustulosis Hyperostosis Osteitis (SAPHO) Syndrome – Two Presentations of the Same Disease?. Acta Dermatovenerologica Croatica, 26 (3), 212-212. Preuzeto s https://hrcak.srce.hr/207007
MLA 8th Edition
Jelušić, Marija, et al. "Chronic Recurrent Multifocal Osteomyelitis (CRMO) and Synovitis Acne Pustulosis Hyperostosis Osteitis (SAPHO) Syndrome – Two Presentations of the Same Disease?." Acta Dermatovenerologica Croatica, vol. 26, br. 3, 2018, str. 212-212. https://hrcak.srce.hr/207007. Citirano 26.10.2021.
Chicago 17th Edition
Jelušić, Marija, Nastasia Čekada, Marijan Frković, Kristina Potočki, Mihael Skerlev, Slobodna Murat-Sušić, Karmela Husar, Tomislav Đapić, Igor Šmigovec i Dubravko Bajramović. "Chronic Recurrent Multifocal Osteomyelitis (CRMO) and Synovitis Acne Pustulosis Hyperostosis Osteitis (SAPHO) Syndrome – Two Presentations of the Same Disease?." Acta Dermatovenerologica Croatica 26, br. 3 (2018): 212-212. https://hrcak.srce.hr/207007
Harvard
Jelušić, M., et al. (2018). 'Chronic Recurrent Multifocal Osteomyelitis (CRMO) and Synovitis Acne Pustulosis Hyperostosis Osteitis (SAPHO) Syndrome – Two Presentations of the Same Disease?', Acta Dermatovenerologica Croatica, 26(3), str. 212-212. Preuzeto s: https://hrcak.srce.hr/207007 (Datum pristupa: 26.10.2021.)
Vancouver
Jelušić M, Čekada N, Frković M, Potočki K, Skerlev M, Murat-Sušić S i sur. Chronic Recurrent Multifocal Osteomyelitis (CRMO) and Synovitis Acne Pustulosis Hyperostosis Osteitis (SAPHO) Syndrome – Two Presentations of the Same Disease?. Acta Dermatovenerol Croat. [Internet]. 2018 [pristupljeno 26.10.2021.];26(3):212-212. Dostupno na: https://hrcak.srce.hr/207007
IEEE
M. Jelušić, et al., "Chronic Recurrent Multifocal Osteomyelitis (CRMO) and Synovitis Acne Pustulosis Hyperostosis Osteitis (SAPHO) Syndrome – Two Presentations of the Same Disease?", Acta Dermatovenerologica Croatica, vol.26, br. 3, str. 212-212, 2018. [Online]. Dostupno na: https://hrcak.srce.hr/207007. [Citirano: 26.10.2021.]

Sažetak

The two most common entities among generally rare but under-diagnosed autoinflammatory bone disorders are chronic recurrent multifocal osteomyelitis (CRMO) and synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome. Due to their similarities, many authors consider CRMO to be a subtype of SAPHO syndrome. The aim of this study was to compare clinical, laboratory, and imaging features and outcomes of patients with CRMO and SAPHO. The analysis of the data from 6 children with CRMO (four girls and two boys, age 3.5-14 years) and of 6 children (6 boys, age 13.5-17.5 years) with SAPHO syndrome was performed. The initiating symptoms in all patients with CRMO were bone pain with multifocal bone lesions. There were no skin manifestations. Five out of six patients achieved control with nonsteroidal anti-inflammatory drugs (NSAIDs) and corticosteroids, while one patient required disease-modifying antirheumatic drugs (DMARDs). The initiating symptom in five patients with SAPHO syndrome were severe acne, while in one patient acne occurred two years after the disease onset. Two patients typically developed inflamed sternoclavicular joints and sternum, while the others showed changes affecting other skeletal regions. Three patients achieved control with NSAIDs and corticosteroids, the others required DMARDs and TNFα inhibitors. In comparison with patients with CRMO, patients with SAPHO suffered more frequent and longer lasting exacerbations. In conclusion, CRMO and SAPHO syndrome have an array of common characteristics, but also a number of differences. Nevertheless, further investigation into the etiopathogenesis is required to establish a definite relationship between CRMO and SAPHO.

 

Ključne riječi
SAPHO syndrome; CRMO; acne conglobata

Hrčak ID: 207007

URI
https://hrcak.srce.hr/207007

Posjeta: 504 *