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Association between Immunofluorescence Pattern and Mucosal Involvement in Patients with Bullous Pemphigoid

Rana Rafiei   ORCID icon orcid.org/0000-0001-6599-0058 ; Skin Research Center, Guilan University of Medical Sciences
Hojat Eftekhari
Leila Yousefkhani
Elahe Rafiei
Abbas Darjani
Narges Alizade
Kaveh Gharaei Nejad
Seyyede Zeinab Azimi
Behnam Rafiee
Sara Najirad

Puni tekst: engleski, PDF (131 KB) str. 243-243 preuzimanja: 115* citiraj
APA 6th Edition
Rafiei, R., Eftekhari, H., Yousefkhani, L., Rafiei, E., Darjani, A., Alizade, N., ... Najirad, S. (2018). Association between Immunofluorescence Pattern and Mucosal Involvement in Patients with Bullous Pemphigoid. Acta Dermatovenerologica Croatica, 26 (3), 243-243. Preuzeto s https://hrcak.srce.hr/207011
MLA 8th Edition
Rafiei, Rana, et al. "Association between Immunofluorescence Pattern and Mucosal Involvement in Patients with Bullous Pemphigoid." Acta Dermatovenerologica Croatica, vol. 26, br. 3, 2018, str. 243-243. https://hrcak.srce.hr/207011. Citirano 25.10.2021.
Chicago 17th Edition
Rafiei, Rana, Hojat Eftekhari, Leila Yousefkhani, Elahe Rafiei, Abbas Darjani, Narges Alizade, Kaveh Gharaei Nejad, Seyyede Zeinab Azimi, Behnam Rafiee i Sara Najirad. "Association between Immunofluorescence Pattern and Mucosal Involvement in Patients with Bullous Pemphigoid." Acta Dermatovenerologica Croatica 26, br. 3 (2018): 243-243. https://hrcak.srce.hr/207011
Harvard
Rafiei, R., et al. (2018). 'Association between Immunofluorescence Pattern and Mucosal Involvement in Patients with Bullous Pemphigoid', Acta Dermatovenerologica Croatica, 26(3), str. 243-243. Preuzeto s: https://hrcak.srce.hr/207011 (Datum pristupa: 25.10.2021.)
Vancouver
Rafiei R, Eftekhari H, Yousefkhani L, Rafiei E, Darjani A, Alizade N i sur. Association between Immunofluorescence Pattern and Mucosal Involvement in Patients with Bullous Pemphigoid. Acta Dermatovenerol Croat. [Internet]. 2018 [pristupljeno 25.10.2021.];26(3):243-243. Dostupno na: https://hrcak.srce.hr/207011
IEEE
R. Rafiei, et al., "Association between Immunofluorescence Pattern and Mucosal Involvement in Patients with Bullous Pemphigoid", Acta Dermatovenerologica Croatica, vol.26, br. 3, str. 243-243, 2018. [Online]. Dostupno na: https://hrcak.srce.hr/207011. [Citirano: 25.10.2021.]

Sažetak

Bullous pemphigoid is an acquired autoimmune subepidermal blistering disease which is associated with mucocutaneous lesions. The type and amount of autoantibody deposition may have a role in mucosal lesions. We studied the association between mucosal involvement and direct immunofluorescence pattern in cutaneous lesions of patients with bullous pemphigoid.

In this retrospective analytical cross-sectional study, we studied the demographic data, clinical presentations, and immunopathological findings of 69 patients with bullous pemphigoid admitted to our hospital 2008-2016. Patients were allocated into two groups on the basis of the mucosal involvement, and direct immunofluorescence patterns were evaluated. The data were analyzed using SPSS version18.

The mean age of patients was 70.9±14.97 (mean ± Standard Deviation) years old. In our study, 56.5% of patients were women. All patients showed deposition of IgG and C3 in the dermoepidermal junction, with different severity. Patients with mucosal involvement (40.6% of cases) had a more prominent deposition of IgG, IgA, and C3 at the dermoepidermal junction compared with patients without mucosal involvement, which represented a statistically significant difference (P<0.05). Logistic regression analysis showed that lower age, IgA, and C3 deposition (P<0.05) were associated with mucosal involvement.

Deposition of IgA and C3 (in addition to IgG) at the dermoepidermal junction seems to be a marker of mucosal involvement in patients with bullous pemphigoid. Attention to direct immunofluorescence pattern in patients with bullous pemphigoid may be helpful in prediction of mucosal involvement in these patients.

 

Ključne riječi
Bullous pemphigoid; direct immunofluorescence; mucosal involvement

Hrčak ID: 207011

URI
https://hrcak.srce.hr/207011

Posjeta: 239 *