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https://doi.org/10.15255/KUI.2018.014

Batch Crystallization of Active Pharmaceutical Ingredient: Kinetics and Equilibrium Modelling

Marko Trampuž   ORCID icon orcid.org/0000-0002-1335-6474 ; Department of Catalysis and Chemical Reaction Engineering, National Institute of Chemistry, Hajdrihova 19, 1001 Ljubljana, Slovenia
Dušan Teslić ; Sandoz Development Centre Slovenia, Lek d. d., Kolodvorska 27, 1234 Mengeš, Slovenia
Blaž Likozar ; Department of Catalysis and Chemical Reaction Engineering, National Institute of Chemistry, Hajdrihova 19, 1001 Ljubljana, Slovenia

Puni tekst: engleski, pdf (1 MB) str. P43-P48 preuzimanja: 75* citiraj
APA 6th Edition
Trampuž, M., Teslić, D. i Likozar, B. (2018). Batch Crystallization of Active Pharmaceutical Ingredient: Kinetics and Equilibrium Modelling. Kemija u industriji, 67 (13 (special issue)), P43-P48. https://doi.org/10.15255/KUI.2018.014
MLA 8th Edition
Trampuž, Marko, et al. "Batch Crystallization of Active Pharmaceutical Ingredient: Kinetics and Equilibrium Modelling." Kemija u industriji, vol. 67, br. 13 (special issue), 2018, str. P43-P48. https://doi.org/10.15255/KUI.2018.014. Citirano 16.07.2020.
Chicago 17th Edition
Trampuž, Marko, Dušan Teslić i Blaž Likozar. "Batch Crystallization of Active Pharmaceutical Ingredient: Kinetics and Equilibrium Modelling." Kemija u industriji 67, br. 13 (special issue) (2018): P43-P48. https://doi.org/10.15255/KUI.2018.014
Harvard
Trampuž, M., Teslić, D., i Likozar, B. (2018). 'Batch Crystallization of Active Pharmaceutical Ingredient: Kinetics and Equilibrium Modelling', Kemija u industriji, 67(13 (special issue)), str. P43-P48. https://doi.org/10.15255/KUI.2018.014
Vancouver
Trampuž M, Teslić D, Likozar B. Batch Crystallization of Active Pharmaceutical Ingredient: Kinetics and Equilibrium Modelling. Kemija u industriji [Internet]. 2018 [pristupljeno 16.07.2020.];67(13 (special issue)):P43-P48. https://doi.org/10.15255/KUI.2018.014
IEEE
M. Trampuž, D. Teslić i B. Likozar, "Batch Crystallization of Active Pharmaceutical Ingredient: Kinetics and Equilibrium Modelling", Kemija u industriji, vol.67, br. 13 (special issue), str. P43-P48, 2018. [Online]. https://doi.org/10.15255/KUI.2018.014

Sažetak
Development of a mathematical model for batch crystallization of fesoterodine fumarate, an active pharmaceutical ingredient, in 2-butanone is presented. The model is based on population, mass and energy balances, and takes into account nucleation, crystal growth and agglomeration. Equilibrium solubility was determined experimentally by ATR-FTIR spectroscopy. Kinetic parameters were determined by fitting of experimental and simulated concentration curves and particle size distributions for six crystallization experiments, performed under different operating conditions. The model was validated and the results show good agreement with experimental data.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

Ključne riječi
pharmaceutical; crystallization; modelling; kinetics; equilibrium; fesoterodine fumarate

Hrčak ID: 207029

URI
https://hrcak.srce.hr/207029

[hrvatski]

Posjeta: 160 *