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https://doi.org/10.2478/v10007-007-0041-5

Ispitivanje antidepresivnog, sedativnog i analgetskog djelovanja novih fuzioniranih derivata tiofena

WAGNAT W. WARDAKHAN
OMAR M. E. ABDEL-SALAM
GAMAL A. ELMEGEED

Puni tekst: engleski, pdf (96 KB) str. 1-14 preuzimanja: 1.184* citiraj
APA 6th Edition
W. WARDAKHAN, W., ABDEL-SALAM, O.M.E. i ELMEGEED, G.A. (2008). Screening for antidepressant, sedative and analgesic activities of novel fused thiophene derivatives. Acta Pharmaceutica, 58 (1), 1-14. https://doi.org/10.2478/v10007-007-0041-5
MLA 8th Edition
W. WARDAKHAN, WAGNAT, et al. "Screening for antidepressant, sedative and analgesic activities of novel fused thiophene derivatives." Acta Pharmaceutica, vol. 58, br. 1, 2008, str. 1-14. https://doi.org/10.2478/v10007-007-0041-5. Citirano 21.06.2019.
Chicago 17th Edition
W. WARDAKHAN, WAGNAT, OMAR M. E. ABDEL-SALAM i GAMAL A. ELMEGEED. "Screening for antidepressant, sedative and analgesic activities of novel fused thiophene derivatives." Acta Pharmaceutica 58, br. 1 (2008): 1-14. https://doi.org/10.2478/v10007-007-0041-5
Harvard
W. WARDAKHAN, W., ABDEL-SALAM, O.M.E., i ELMEGEED, G.A. (2008). 'Screening for antidepressant, sedative and analgesic activities of novel fused thiophene derivatives', Acta Pharmaceutica, 58(1), str. 1-14. doi: https://doi.org/10.2478/v10007-007-0041-5
Vancouver
W. WARDAKHAN W, ABDEL-SALAM OME, ELMEGEED GA. Screening for antidepressant, sedative and analgesic activities of novel fused thiophene derivatives. Acta Pharm. [Internet]. 2008 [pristupljeno 21.06.2019.];58(1):1-14. doi: https://doi.org/10.2478/v10007-007-0041-5
IEEE
W. W. WARDAKHAN, O.M.E. ABDEL-SALAM i G.A. ELMEGEED, "Screening for antidepressant, sedative and analgesic activities of novel fused thiophene derivatives", Acta Pharmaceutica, vol.58, br. 1, str. 1-14, 2008. [Online]. doi: https://doi.org/10.2478/v10007-007-0041-5

Sažetak
U radu je opisana sinteza fuzioniranih derivata benzotiofena koji sadrže heterociklički ostatak bitan za farmakološko djelovanje. Tiourea derivati 2a,b dobiveni su reakcijom derivata tetrahidrobenzo[b]tiofena 1a,b s etoksikarbonilizotiocijanatom. Iz njih su dalje priređeni anulirani derivati benzo[b]tienopirimidina 3a,b. Spojevi 2a,b i 3a prevedeni su reakcijama heterociklizacije u benzo[b]tienopirimidine 5a,b-8a-c. Ispitivano je antidepresivno, sedativno i analgetsko djelovanje novosintetiziranih derivata tiouree 2a i benzo[b]tienopirimidina 3a, 5b, 6a i 8b u dvije doze (15 ili 30 mg kg1 tjelesne mase). Spojevi 2a, 3a i 5b pokazali su blago antidepresivno djelovanje u testu forsiranog plivanja, dok sedativni učinak nije pokazao niti jedan ispitivani spoj. Visceralna bol inducirana i.p. injekcijom octene kiseline u miševa značajno je inhibirana sa svim spojevima, ali u visokim dozama.

Ključne riječi
tetrahidrobenzo[b]tiofen; pirimidin; tiourea; antidepresiv; sedativ; analgetik

Hrčak ID: 19473

URI
https://hrcak.srce.hr/19473

[engleski]

Posjeta: 1.573 *