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https://doi.org/10.2478/v10007-007-0041-5

Screening for antidepressant, sedative and analgesic activities of novel fused thiophene derivatives

WAGNAT W. WARDAKHAN
OMAR M. E. ABDEL-SALAM
GAMAL A. ELMEGEED

Puni tekst: engleski, pdf (96 KB) str. 1-14 preuzimanja: 1.184* citiraj
APA 6th Edition
W. WARDAKHAN, W., ABDEL-SALAM, O.M.E. i ELMEGEED, G.A. (2008). Screening for antidepressant, sedative and analgesic activities of novel fused thiophene derivatives. Acta Pharmaceutica, 58 (1), 1-14. https://doi.org/10.2478/v10007-007-0041-5
MLA 8th Edition
W. WARDAKHAN, WAGNAT, et al. "Screening for antidepressant, sedative and analgesic activities of novel fused thiophene derivatives." Acta Pharmaceutica, vol. 58, br. 1, 2008, str. 1-14. https://doi.org/10.2478/v10007-007-0041-5. Citirano 25.06.2019.
Chicago 17th Edition
W. WARDAKHAN, WAGNAT, OMAR M. E. ABDEL-SALAM i GAMAL A. ELMEGEED. "Screening for antidepressant, sedative and analgesic activities of novel fused thiophene derivatives." Acta Pharmaceutica 58, br. 1 (2008): 1-14. https://doi.org/10.2478/v10007-007-0041-5
Harvard
W. WARDAKHAN, W., ABDEL-SALAM, O.M.E., i ELMEGEED, G.A. (2008). 'Screening for antidepressant, sedative and analgesic activities of novel fused thiophene derivatives', Acta Pharmaceutica, 58(1), str. 1-14. doi: https://doi.org/10.2478/v10007-007-0041-5
Vancouver
W. WARDAKHAN W, ABDEL-SALAM OME, ELMEGEED GA. Screening for antidepressant, sedative and analgesic activities of novel fused thiophene derivatives. Acta Pharm. [Internet]. 2008 [pristupljeno 25.06.2019.];58(1):1-14. doi: https://doi.org/10.2478/v10007-007-0041-5
IEEE
W. W. WARDAKHAN, O.M.E. ABDEL-SALAM i G.A. ELMEGEED, "Screening for antidepressant, sedative and analgesic activities of novel fused thiophene derivatives", Acta Pharmaceutica, vol.58, br. 1, str. 1-14, 2008. [Online]. doi: https://doi.org/10.2478/v10007-007-0041-5

Sažetak
This study was aimed at the synthesis of fused benzothiophene derivatives containing heterocyclic moiety. The reaction of the tetrahydrobenzo[b]thiophene derivatives 1a,b with ethoxycarbonylisothiocyanate afforded the thiourea derivatives 2a,b. Cyclization of the latter products gave the annulated benzo[b]thienopyrimidine derivatives 3a,b. Compounds 2a,b and 3a underwent a series of heterocyclization reactions through the reaction with some chemical reagents to give the new benzo[b]thienopyrimidine derivatives 5a,b to 8a-c. Also, this work was extended to study the potential role of the novel synthesized thiourea derivative 2a and benzo[b]thienopyrimidine derivatives 3a, 5b, 6a and 8b as antidepressant, sedative or analgesic agents at two doses (15 or 30 mg kg1 body mass). Some compounds (2a, 3a and 5b) showed mild antidepressant activity in the forced-swimming test. No compound showed sedative effect. Visceral pain evoked by i.p. injection of acetic acid in mice was significantly inhibited by all compounds at a high doses.

Ključne riječi
tetrahydrobenzo[b]thiophene; pyrimidine; thiourea; antidepressant; sedative; analgesic

Hrčak ID: 19473

URI
https://hrcak.srce.hr/19473

[hrvatski]

Posjeta: 1.573 *