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Acta clinica Croatica, Vol. 57 No. 2, 2018.

Izvorni znanstveni članak
https://doi.org/10.20471/acc.2018.57.02.09

Indeks ALBI kao prediktor preživljenja nakon resekcije hepatocelularnog karcinoma u bolesnika s kompenziranom cirozom jetre: usporedba s indeksima PALBI i MELD

Tonći Božin ; Department of Gastroenterology, Hepatology and Clinical Nutrition, Dubrava University Hospital, Zagreb, Croatia;
Sanda Mustapić ; Department of Gastroenterology, Hepatology and Clinical Nutrition, Dubrava University Hospital, Zagreb, Croatia;
Tomislav Bokun ; Department of Gastroenterology, Hepatology and Clinical Nutrition, Dubrava University Hospital, Zagreb, Croatia;
Leonardo Patrlj ; Department of Abdominal Surgery, Dubrava University Hospital, Zagreb, Croatia; University of Zagreb, School of Medicine, Zagreb, Croatia;
Mislav Rakić ; Department of Abdominal Surgery, Dubrava University Hospital, Zagreb, Croatia;
Gorana Aralica ; University of Zagreb, School of Medicine, Zagreb, Croatia; Department of Pathology, Dubrava University Hospital, Zagreb, Croatia;
Milan Kujundžić ; Department of Gastroenterology, Hepatology and Clinical Nutrition, Dubrava University Hospital, Zagreb, Croatia; University of Zagreb, School of Medicine, Zagreb, Croatia;
Vladimir Trkulja ; Department of Pharmacology, University of Zagreb, School of Medicine, Zagreb, Croatia
Ivica Grgurević   ORCID icon orcid.org/0000-0003-0520-3483 ; Department of Gastroenterology, Hepatology and Clinical Nutrition, Dubrava University Hospital, Zagreb, Croatia;University of Zagreb, School of Medicine, Zagreb, Croatia;

Puni tekst: engleski, pdf (751 KB) str. 292-300 preuzimanja: 41* citiraj
APA 6th Edition
Božin, T., Mustapić, S., Bokun, T., Patrlj, L., Rakić, M., Aralica, G., ... Grgurević, I. (2018). ALBI Score as a Predictor of Survival in Patients with Compensated Cirrhosis Resected for Hepatocellular Carcinoma: Exploratory Evaluation in Relationship to PALBI and MELD Liver Function Scores. Acta clinica Croatica, 57 (2), 292-300. https://doi.org/10.20471/acc.2018.57.02.09
MLA 8th Edition
Božin, Tonći, et al. "ALBI Score as a Predictor of Survival in Patients with Compensated Cirrhosis Resected for Hepatocellular Carcinoma: Exploratory Evaluation in Relationship to PALBI and MELD Liver Function Scores." Acta clinica Croatica, vol. 57, br. 2, 2018, str. 292-300. https://doi.org/10.20471/acc.2018.57.02.09. Citirano 20.02.2019.
Chicago 17th Edition
Božin, Tonći, Sanda Mustapić, Tomislav Bokun, Leonardo Patrlj, Mislav Rakić, Gorana Aralica, Milan Kujundžić, Vladimir Trkulja i Ivica Grgurević. "ALBI Score as a Predictor of Survival in Patients with Compensated Cirrhosis Resected for Hepatocellular Carcinoma: Exploratory Evaluation in Relationship to PALBI and MELD Liver Function Scores." Acta clinica Croatica 57, br. 2 (2018): 292-300. https://doi.org/10.20471/acc.2018.57.02.09
Harvard
Božin, T., et al. (2018). 'ALBI Score as a Predictor of Survival in Patients with Compensated Cirrhosis Resected for Hepatocellular Carcinoma: Exploratory Evaluation in Relationship to PALBI and MELD Liver Function Scores', Acta clinica Croatica, 57(2), str. 292-300. doi: https://doi.org/10.20471/acc.2018.57.02.09
Vancouver
Božin T, Mustapić S, Bokun T, Patrlj L, Rakić M, Aralica G i sur. ALBI Score as a Predictor of Survival in Patients with Compensated Cirrhosis Resected for Hepatocellular Carcinoma: Exploratory Evaluation in Relationship to PALBI and MELD Liver Function Scores. Acta clinica Croatica [Internet]. 2018 [pristupljeno 20.02.2019.];57(2):292-300. doi: https://doi.org/10.20471/acc.2018.57.02.09
IEEE
T. Božin, et al., "ALBI Score as a Predictor of Survival in Patients with Compensated Cirrhosis Resected for Hepatocellular Carcinoma: Exploratory Evaluation in Relationship to PALBI and MELD Liver Function Scores", Acta clinica Croatica, vol.57, br. 2, str. 292-300, 2018. [Online]. doi: https://doi.org/10.20471/acc.2018.57.02.09

Sažetak
Cilj je bio istražiti prediktivnu vrijednost zbira ALBI, PALBI i MELD za preživljenje bolesnika s kompenziranom cirozom reseciranih zbog hepatocelularnog karcinoma bez makrovaskularne invazije. Provedena je retrospektivna longitudinalna analiza preživljenja. Testirane su karakteristike bolesnika/tumora kao i jetreni funkcijski testovi MELD, ALBI i PALBI za predviđanje preživljenja. Bolesnici su praćeni nakon resekcije jetre do smrti, transplantacije jetre odnosno do kraja vremena praćenja. Bolesnici su kategorizirani po dobi, etiologiji ciroze, prisutnosti varikoziteta jednjaka, stadiju karcinoma, mikrovaskularnoj invaziji, histološkom stadiju i resekcijskim rubovima. Identifi cirali smo 38 bolesnika (alkoholna ciroza kod 84,2% bolenika) reseciranih kroz razdoblje od 8 godina. Medijan prijeoperacijskog zbira MELD bio je 8, zbira ALBI -2,63 i zbira PALBI -2,38. Tijekom praćenja 24 bolesnika su umrla. Očekivani medijan preživljenja iznosio je 36 mjeseci. Mikrovaskularna invazija pronađena je u 33 bolesnika. Veći ALBI je bio povezan s 23,1%, a PALBI s 12,1% većim relativnim rizikom od smrtnog ishoda. MELD nije bio povezan sa smrtnim ishodom. Zbir ALBI je pokazao značajnu prediktivnu vrijednost preživljenja u skupini bolesnika s kompenziranom cirozom reseciranih zbog hepatocelularnog karcinoma.

Ključne riječi
karcinom, hepatocelularni; jetrena ciroza; jetra, ispitivanje funkcije; hepatektomija; jetra, transplantacija; ezofagusni i želučani varikoziteti; jetrena ciroza, alkoholna; kontrolne studije; preživljavanje

Hrčak ID: 207543

URI
https://hrcak.srce.hr/207543

[engleski]

Posjeta: 99 *