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Acta clinica Croatica, Vol. 57 No. 2, 2018.

Izvorni znanstveni članak
https://doi.org/10.20471/acc.2018.57.02.11

Comparison of Different Diagnostic Guidelines for the Diagnosis of Macrophage Activation Syndrome Complicating Systemic Juvenile Idiopathic Arthritis: Single Centre Experience

Marija Jelušić   ORCID icon orcid.org/0000-0002-1728-4260 ; Department of Pediatrics, Zagreb University Hospital Centre; University of Zagreb School of Medicine, Zagreb, Croatia
Matea Kronja ; Department of Pediatrics, Zagreb University Hospital Centre; University of Zagreb School of Medicine, Zagreb, Croatia
Marijan Frković ; Department of Pediatrics, Zagreb University Hospital Centre; University of Zagreb School of Medicine, Zagreb, Croatia
Saša Sršen   ORCID icon orcid.org/0000-0001-6555-2613 ; Department of Pediatrics, Zagreb University Hospital Centre; University of Zagreb School of Medicine, Zagreb, Croatia
Sanda Huljev Frković ; Department of Pediatrics, Zagreb University Hospital Centre; University of Zagreb School of Medicine, Zagreb, Croatia
Ksenija Štekić Novački ; Department of Pediatrics, Zagreb University Hospital Centre; University of Zagreb School of Medicine, Zagreb, Croatia

Puni tekst: engleski, pdf (464 KB) str. 307-310 preuzimanja: 46* citiraj
APA 6th Edition
Jelušić, M., Kronja, M., Frković, M., Sršen, S., Huljev Frković, S. i Štekić Novački, K. (2018). Comparison of Different Diagnostic Guidelines for the Diagnosis of Macrophage Activation Syndrome Complicating Systemic Juvenile Idiopathic Arthritis: Single Centre Experience. Acta clinica Croatica, 57 (2), 307-310. https://doi.org/10.20471/acc.2018.57.02.11
MLA 8th Edition
Jelušić, Marija, et al. "Comparison of Different Diagnostic Guidelines for the Diagnosis of Macrophage Activation Syndrome Complicating Systemic Juvenile Idiopathic Arthritis: Single Centre Experience." Acta clinica Croatica, vol. 57, br. 2, 2018, str. 307-310. https://doi.org/10.20471/acc.2018.57.02.11. Citirano 23.02.2019.
Chicago 17th Edition
Jelušić, Marija, Matea Kronja, Marijan Frković, Saša Sršen, Sanda Huljev Frković i Ksenija Štekić Novački. "Comparison of Different Diagnostic Guidelines for the Diagnosis of Macrophage Activation Syndrome Complicating Systemic Juvenile Idiopathic Arthritis: Single Centre Experience." Acta clinica Croatica 57, br. 2 (2018): 307-310. https://doi.org/10.20471/acc.2018.57.02.11
Harvard
Jelušić, M., et al. (2018). 'Comparison of Different Diagnostic Guidelines for the Diagnosis of Macrophage Activation Syndrome Complicating Systemic Juvenile Idiopathic Arthritis: Single Centre Experience', Acta clinica Croatica, 57(2), str. 307-310. doi: https://doi.org/10.20471/acc.2018.57.02.11
Vancouver
Jelušić M, Kronja M, Frković M, Sršen S, Huljev Frković S, Štekić Novački K. Comparison of Different Diagnostic Guidelines for the Diagnosis of Macrophage Activation Syndrome Complicating Systemic Juvenile Idiopathic Arthritis: Single Centre Experience. Acta clinica Croatica [Internet]. 2018 [pristupljeno 23.02.2019.];57(2):307-310. doi: https://doi.org/10.20471/acc.2018.57.02.11
IEEE
M. Jelušić, M. Kronja, M. Frković, S. Sršen, S. Huljev Frković i K. Štekić Novački, "Comparison of Different Diagnostic Guidelines for the Diagnosis of Macrophage Activation Syndrome Complicating Systemic Juvenile Idiopathic Arthritis: Single Centre Experience", Acta clinica Croatica, vol.57, br. 2, str. 307-310, 2018. [Online]. doi: https://doi.org/10.20471/acc.2018.57.02.11

Sažetak
Macrophage activation syndrome (MAS) is a potentially fatal complication of systemic juvenile idiopathic arthritis (sJIA), caused by exaggerated but ineff ective immune response. The aim of the study was to compare the capacity of the HLH-2004 guidelines with the capacity of the MAS guidelines from 2005, and with the new set of classifi cation criteria from 2016 in diagnosing MAS complicating sJIA. Th e study included 35 children aged 1-18 diagnosed with sJIA according to ILAR criteria and treated at the Department of Pediatrics, Division of Immunology and Rheumatology, Zagreb University Hospital Centre, in the period from 2009 to 2015. Out of 35 patients diagnosed with sJIA, there were 12 girls and 23 boys, with the mean age at disease onset (±SD) 5.51±3.65 years. Eight patients had fl are of disease. With the guidelines from 2005, MAS was diagnosed in six (17.1%) patients with sJIA. With the new set of classifi cation criteria from 2016, MAS was diagnosed in four (11.4%) patients with sJIA. MAS was not diagnosed with the HLH-2004 guidelines. In our study, four out of six patients had MAS at the onset of sJIA, and in the rest two it occurred during relapse. Two patients with MAS developed full-blown clinical picture while another four had incomplete clinical features with minor laboratory alteration. Due to the use of diff erent diagnostic guidelines, we found diff erence in the prevalence of MAS. It was slightly higher in comparison to available studies, while other researched features, such as clinical characteristics, were similar.

Ključne riječi
Macrophage Activation Syndrome; Arthritis, Juvenile; Child; Croatia; Lymphohistiocytosis, Hemophagocytic

Hrčak ID: 207545

URI
https://hrcak.srce.hr/207545

[hrvatski]

Posjeta: 99 *