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Erythromycin Series. II. Acylation of Erythromycin oxime and 9-Amino-3-0-cladinosyl-5-0-desosaminyl-6,11,12-trihydroxy- 2,4,6,8,10,12-hexamethylpentadecane-13-olide with Ester-chlorides of Dicarboxylic Acids

Z. Tamburašev ; Research Department Pliva, Pharmaceutical and Chemical Works, Zagreb, ' Croatia, Yugoslavia
G. Vazdar ; Research Department Pliva, Pharmaceutical and Chemical Works, Zagreb, ' Croatia, Yugoslavia
S. Djokić ; Research Department Pliva, Pharmaceutical and Chemical Works, Zagreb, ' Croatia, Yugoslavia


Puni tekst: engleski pdf 4.435 Kb

str. 273-276

preuzimanja: 216

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Sažetak

The acylation of erythromycin oxime and 9-amino-3-0-cladinosyl-
5-0-desosaminyl-6,11,12 - trihydroxy-2,4,6,8,10,1 2 - hexamethylpentadecane-
13-olide (erythromycyl amine) was performed by
means of dicarboxylic acid chloride esters and the corresponding
0- and N-acyl derivati ves were obtained. A comparison of the
physical p ro perties and antibiotic activity of these compounds
with those of corresponding erythromycin esters shows that erythromycin
oxime and erythromycyl amine are very similar to erythromycin
itself in their chemical and antimicrobial behaviour.

Ključne riječi

Hrčak ID:

208073

URI

https://hrcak.srce.hr/208073

Datum izdavanja:

15.2.1968.

Posjeta: 494 *