hrcak mascot   Srce   HID

Izvorni znanstveni članak

Hydropyrimidines. VII. Covalent Hydration and Ring Opening

V. Škarić ; Institute »Ruder Boskovic«, Zagreb, Croatia, Yugoslavia
B. Gašpert ; Institute »Ruder Boskovic«, Zagreb, Croatia, Yugoslavia

Puni tekst: engleski, pdf (6 MB) str. 65-70 preuzimanja: 42* citiraj
APA 6th Edition
Škarić, V. i Gašpert, B. (1967). Hydropyrimidines. VII. Covalent Hydration and Ring Opening. Croatica Chemica Acta, 39 (2), 65-70. Preuzeto s https://hrcak.srce.hr/208091
MLA 8th Edition
Škarić, V. i B. Gašpert. "Hydropyrimidines. VII. Covalent Hydration and Ring Opening." Croatica Chemica Acta, vol. 39, br. 2, 1967, str. 65-70. https://hrcak.srce.hr/208091. Citirano 07.03.2021.
Chicago 17th Edition
Škarić, V. i B. Gašpert. "Hydropyrimidines. VII. Covalent Hydration and Ring Opening." Croatica Chemica Acta 39, br. 2 (1967): 65-70. https://hrcak.srce.hr/208091
Harvard
Škarić, V., i Gašpert, B. (1967). 'Hydropyrimidines. VII. Covalent Hydration and Ring Opening', Croatica Chemica Acta, 39(2), str. 65-70. Preuzeto s: https://hrcak.srce.hr/208091 (Datum pristupa: 07.03.2021.)
Vancouver
Škarić V, Gašpert B. Hydropyrimidines. VII. Covalent Hydration and Ring Opening. Croatica Chemica Acta [Internet]. 1967 [pristupljeno 07.03.2021.];39(2):65-70. Dostupno na: https://hrcak.srce.hr/208091
IEEE
V. Škarić i B. Gašpert, "Hydropyrimidines. VII. Covalent Hydration and Ring Opening", Croatica Chemica Acta, vol.39, br. 2, str. 65-70, 1967. [Online]. Dostupno na: https://hrcak.srce.hr/208091. [Citirano: 07.03.2021.]

Sažetak
The ring opening of 5,6-dihydro-4-oxo-pyrimidine (I) and its
N-methyl d erivatives II and III has been e1>tab lished as the cleavage
of the intermediary 2-hydroxytetrahydropyrimidines to 3-forma midopropionamide (VIII) and its N-methyl d e rivatives XIII and XIV.
The formation of the 2-hydroxy intermediate is proposed as the
nucleophylic addition of water to the C = N double bond of the
hydropyrimidines I-III. The rupture of 1,3 -dime thyl-5,6-dihydro-2-thioura cil (VII) procee ds to 3-(N-methyl-forma mido)-N-methylpropionamide (XV), most probably by reductive desulfurization via a carbonium ion of the mentioned type during nucleophylic addition.
The NMR spectra of formamidopropionamide are discussed.

Hrčak ID: 208091

URI
https://hrcak.srce.hr/208091

Posjeta: 86 *