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The Mannich Reaction for 2,5-Dimercapto-1,3,4-thiadiazole

J. Kobe ; Department of Chemistry, University of Ljubljana, Ljubljana, Slovenia, Yugoslavia
A. Pollak ; Department of Chemistry, University of Ljubljana, Ljubljana, Slovenia, Yugoslavia
B. Stanovnik ; Department of Chemistry, University of Ljubljana, Ljubljana, Slovenia, Yugoslavia
M. Tišler ; Department of Chemistry, University of Ljubljana, Ljubljana, Slovenia, Yugoslavia

Puni tekst: engleski, pdf (7 MB) str. 215-221 preuzimanja: 101* citiraj
APA 6th Edition
Kobe, J., Pollak, A., Stanovnik, B. i Tišler, M. (1965). The Mannich Reaction for 2,5-Dimercapto-1,3,4-thiadiazole. Croatica Chemica Acta, 37 (4), 215-221. Preuzeto s https://hrcak.srce.hr/208190
MLA 8th Edition
Kobe, J., et al. "The Mannich Reaction for 2,5-Dimercapto-1,3,4-thiadiazole." Croatica Chemica Acta, vol. 37, br. 4, 1965, str. 215-221. https://hrcak.srce.hr/208190. Citirano 28.02.2021.
Chicago 17th Edition
Kobe, J., A. Pollak, B. Stanovnik i M. Tišler. "The Mannich Reaction for 2,5-Dimercapto-1,3,4-thiadiazole." Croatica Chemica Acta 37, br. 4 (1965): 215-221. https://hrcak.srce.hr/208190
Harvard
Kobe, J., et al. (1965). 'The Mannich Reaction for 2,5-Dimercapto-1,3,4-thiadiazole', Croatica Chemica Acta, 37(4), str. 215-221. Preuzeto s: https://hrcak.srce.hr/208190 (Datum pristupa: 28.02.2021.)
Vancouver
Kobe J, Pollak A, Stanovnik B, Tišler M. The Mannich Reaction for 2,5-Dimercapto-1,3,4-thiadiazole. Croatica Chemica Acta [Internet]. 1965 [pristupljeno 28.02.2021.];37(4):215-221. Dostupno na: https://hrcak.srce.hr/208190
IEEE
J. Kobe, A. Pollak, B. Stanovnik i M. Tišler, "The Mannich Reaction for 2,5-Dimercapto-1,3,4-thiadiazole", Croatica Chemica Acta, vol.37, br. 4, str. 215-221, 1965. [Online]. Dostupno na: https://hrcak.srce.hr/208190. [Citirano: 28.02.2021.]

Sažetak
The formation of Mannich bases with 2,5-dimercapto-1,3,4-
-thiadiazole (III) and some of its derivatives has been investigated.
Depending on the amount of formaldehyde and a secondary amine
used in the reaction, three different types of Mannich bases were
prepared. With equimolecular amounts of both reagents a mono-
Mannich base IV was obtained, but using formaldehyde in excess
a mono-hydroxymethyl mono-M.annich base V was isolated. If both
reagents were used in amounts corresponding to two equivalents, a
bis-Mannich base VI was formed. Evidence- for the structures of all
these products was presented on the basis of chemical transformatfons
and spectroscopic data. The mono-Mannich base IV .was
converted in its S-methyl derivative VIII which was prepared
independently from IX in a Mannich reaction. Thus aminoalkylation
proceeds first on the ring nitrogen and in a further reaction the
exo-cyclic sulfur is substituted.

Hrčak ID: 208190

URI
https://hrcak.srce.hr/208190

Posjeta: 138 *