Stručni rad

Klonazepam augmentation during treatment with antipsychotics in aggressive inpatients - pilot study

Ninoslav Mimica ; University psychiatric hospital Vrapče, Zagreb, Croatia; University of Zagreb, School of medicine
Suzana Uzun ; University psychiatric hospital Vrapče, Zagreb, Croatia; University of Osijek Josip Juraj Strossmayer, Faculty of medicine
Gordan Makarić ; University psychiatric hospital Vrapče, Zagreb, Croatia
Oliver Kozumplik ; University psychiatric hospital Vrapče, Zagreb, Croatia; University of Osijek Josip Juraj Strossmayer, Faculty of medicine
Tajana Ljubin Golub ; University of Zagreb, Faculty of teacher education
Petra Folnegović Grošić ; University hospital centre Zagreb, Department of psychiatry

Sažetak

Introduction: The interest in studies related to aggressive behaviour in psychiatric patients has increased over time. Various factors are considered as determinants of aggression, such as social, environmental and situational determinants, hormones, drugs and other substances, neurotransmitters and genetic determinants. Methods: Clonazepam was initially administered at a daily dose of 2 mg to all patients in the study. If satisfactory clinical improvement was not observed in 2 days, it was allowed to increase the dose up to a daily dose of 6 mg. Aggression was twice evaluated by the Social Dysfunction and Aggression Scale (SDAS): the first time at the moment of inclusion to the study, and second time 3 days after the administration of clonazepam. Results: The results of our research show the efficiency of clonazepam as a serenic drug in combination with antipsychotic drug in the treatment of aggressive patients. It is particularly encouraging that no adverse effects of clonazepam were observed in this study. Conclusion: Further relevant trials are needed to evaluate the use of clonazepam in treatment of longterm/persistent aggression in people living with psychosis.

Ključne riječi

aggression; antipsychotic; clonazepam; patient; psychosis

Hrčak ID:

208255

URI

https://hrcak.srce.hr/208255

Datum izdavanja:

6.11.2018.

Podaci na drugim jezicima: hrvatski

Posjeta: 1.509 *