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https://doi.org/10.2478/v10007-007-0043-3

Synthesis of progesterone heterocyclic derivatives of potential antimicrobial activity

RAFAT M. MOHAREB
HANAA Y. HANA

Puni tekst: engleski, pdf (98 KB) str. 29-42 preuzimanja: 1.503* citiraj
APA 6th Edition
MOHAREB, R.M. i HANA, H.Y. (2008). Synthesis of progesterone heterocyclic derivatives of potential antimicrobial activity. Acta Pharmaceutica, 58 (1), 29-42. https://doi.org/10.2478/v10007-007-0043-3
MLA 8th Edition
MOHAREB, RAFAT M. i HANAA Y. HANA. "Synthesis of progesterone heterocyclic derivatives of potential antimicrobial activity." Acta Pharmaceutica, vol. 58, br. 1, 2008, str. 29-42. https://doi.org/10.2478/v10007-007-0043-3. Citirano 21.06.2019.
Chicago 17th Edition
MOHAREB, RAFAT M. i HANAA Y. HANA. "Synthesis of progesterone heterocyclic derivatives of potential antimicrobial activity." Acta Pharmaceutica 58, br. 1 (2008): 29-42. https://doi.org/10.2478/v10007-007-0043-3
Harvard
MOHAREB, R.M., i HANA, H.Y. (2008). 'Synthesis of progesterone heterocyclic derivatives of potential antimicrobial activity', Acta Pharmaceutica, 58(1), str. 29-42. doi: https://doi.org/10.2478/v10007-007-0043-3
Vancouver
MOHAREB RM, HANA HY. Synthesis of progesterone heterocyclic derivatives of potential antimicrobial activity. Acta Pharm. [Internet]. 2008 [pristupljeno 21.06.2019.];58(1):29-42. doi: https://doi.org/10.2478/v10007-007-0043-3
IEEE
R.M. MOHAREB i H.Y. HANA, "Synthesis of progesterone heterocyclic derivatives of potential antimicrobial activity", Acta Pharmaceutica, vol.58, br. 1, str. 29-42, 2008. [Online]. doi: https://doi.org/10.2478/v10007-007-0043-3

Sažetak
The aim of this work was to synthesize steroidal heterocycles and to elucidate the potential role of these compounds as antimicrobial agents. The synthesis of steroidal heterocycles containing the pyrazole, isoxazole, thiazole, pyrane, pyridine, pyridazine, or benzopyrane ring attached to the pregnene nucleus is reported. Progesterone (1) reacts with dimethyl formamide dimethyl acetal to form enamine 2. Heterocyclization of 2 with hydrazines, hydroxylamine, glycine, ethylacetoacetate or cyanomethylene afforded novel steroidal heterocyclic derivatives. The in vitro antimicrobial evaluation showed that all synthesized compounds show activity against the used strains of Gram positive bacteria and fungi.

Ključne riječi
progesterone; enamine; pyrazole; pyrane; antimicrobial

Hrčak ID: 19685

URI
https://hrcak.srce.hr/19685

[hrvatski]

Posjeta: 1.831 *