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Kratko priopćenje
https://doi.org/10.2478/v10007-007-0049-x

Use of Folin-Ciocalteu phenol reagent and 3-methyl-2-benzothiazolinone hydrazine hydrochloride in the determination of oxcarbazepine in pharmaceuticals

GANDHIMATHI MURUGANATHAN
KOCHUPAPPY R THENGUNGAL

Puni tekst: engleski, pdf (64 KB) str. 111-117 preuzimanja: 2.701* citiraj
APA 6th Edition
MURUGANATHAN, G. i THENGUNGAL, K.R. (2008). Use of Folin-Ciocalteu phenol reagent and 3-methyl-2-benzothiazolinone hydrazine hydrochloride in the determination of oxcarbazepine in pharmaceuticals. Acta Pharmaceutica, 58 (1), 111-117. https://doi.org/10.2478/v10007-007-0049-x
MLA 8th Edition
MURUGANATHAN, GANDHIMATHI i KOCHUPAPPY R THENGUNGAL. "Use of Folin-Ciocalteu phenol reagent and 3-methyl-2-benzothiazolinone hydrazine hydrochloride in the determination of oxcarbazepine in pharmaceuticals." Acta Pharmaceutica, vol. 58, br. 1, 2008, str. 111-117. https://doi.org/10.2478/v10007-007-0049-x. Citirano 23.10.2019.
Chicago 17th Edition
MURUGANATHAN, GANDHIMATHI i KOCHUPAPPY R THENGUNGAL. "Use of Folin-Ciocalteu phenol reagent and 3-methyl-2-benzothiazolinone hydrazine hydrochloride in the determination of oxcarbazepine in pharmaceuticals." Acta Pharmaceutica 58, br. 1 (2008): 111-117. https://doi.org/10.2478/v10007-007-0049-x
Harvard
MURUGANATHAN, G., i THENGUNGAL, K.R. (2008). 'Use of Folin-Ciocalteu phenol reagent and 3-methyl-2-benzothiazolinone hydrazine hydrochloride in the determination of oxcarbazepine in pharmaceuticals', Acta Pharmaceutica, 58(1), str. 111-117. https://doi.org/10.2478/v10007-007-0049-x
Vancouver
MURUGANATHAN G, THENGUNGAL KR. Use of Folin-Ciocalteu phenol reagent and 3-methyl-2-benzothiazolinone hydrazine hydrochloride in the determination of oxcarbazepine in pharmaceuticals. Acta Pharm. [Internet]. 2008 [pristupljeno 23.10.2019.];58(1):111-117. https://doi.org/10.2478/v10007-007-0049-x
IEEE
G. MURUGANATHAN i K.R. THENGUNGAL, "Use of Folin-Ciocalteu phenol reagent and 3-methyl-2-benzothiazolinone hydrazine hydrochloride in the determination of oxcarbazepine in pharmaceuticals", Acta Pharmaceutica, vol.58, br. 1, str. 111-117, 2008. [Online]. https://doi.org/10.2478/v10007-007-0049-x

Sažetak
Two spectrophotometric methods are proposed for the assay of oxcarbazepine (OXC) in bulk and dosage forms using Folin-Ciocalteu phenol reagent (FCP) and 3-methyl-2-benzothiazolinone hydrazine hydrochloride (MBTH) as reagents. The first method involves addition of FCP reagent to OXC in alkaline medium followed by measurement of absorbance at 760 nm (method A), and the other involves addition of a fixed volume of MBTH after treatment of OXC with ferric chloride and measurement of absorbance at 456 nm (method B). In both methods, the amount of chromogen formed corresponds to the amount of OXC and the measured absorbance was found to increase linearly with the concentration of OXC, which is corroborated by the correlation coefficients of 0.9985 and 0.9984 for method A and B, respectively. The systems obey Beer’s law for 530 µg mL1 and 1050 µg mL1 for methods A and B, respectively. The apparent molar absorptivity was calculated to be 8.06 × 103 L mol1 cm1 and 3.126 × 103 L mol1 cm1 for methods A and B, respectively. The limits of detection (LOD) and limit of quantification (LOQ) were calculated to be 1.6 and 5 µg mL1 for method A and 3 and 10 µg mL1 for method B. The inter-day and intra-day imprecision of the methods were found to be in the range of 1.11.7 and 0.91.1 % for method A, and 1.11.9 and 0.60.9 % for method B. The accuracy ranged between 98.999.7 % and 99.3100.1 for method A and B, respectively. No interference was observed from common pharmaceutical excipients. The methods were successfully applied to the assay of OXC in tablet preparations.

Ključne riječi
oxcarbazepine; spectrophotometry; Folin-Ciocalteu reagent; 3-methyl-2-benzothiazolinone hydrazine hydrochloride; pharmaceuticals; validation

Hrčak ID: 19807

URI
https://hrcak.srce.hr/19807

[hrvatski]

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