Izvorni znanstveni članak
https://doi.org/10.26332/seemedj.v2i1.72
The Use of Hydrogen Sulfide Donor in Cardiac Control During Low Doses of Ionizing Radiation (Experimental Study)
Iryna Kovalchuk
; Department of Physiology, Danylo Halytsky Lviv National Medical University, Ukraine
Mechyslav Gzhegotskyi
; Department of Physiology, Danylo Halytsky Lviv National Medical University, Ukraine
Svitlana Kovalchuk
; Department of Physiology, Danylo Halytsky Lviv National Medical University, Ukraine
Vasyl Dukach
; Department of Physiology, Danylo Halytsky Lviv National Medical University, Ukraine
Sažetak
Aim: To analyze the influence of the hydrogen sulfide donor NaHS on the cardiac control in rats during low doses of ionizing radiation and characterize the predictors of imbalance in autonomic nervous system activities.
Methods: Adult male rats were treated once with NaHS 7.4 mg/kg, i.p. or vehicle (saline), without and with total body irradiation (TBI). The irradiation of animals in experimental groups was single-fractional, total, with total absorbed dose – 2 Gy. Heart rate variability (HRV) was recorded in rats after 30 minutes with NaHS pre-treatment, 24 h of TBI exposure and NaHS and TBI combination.
Results: HRV analysis revealed that low doses of radiation cause cardiac autonomic dysfunction. TBI rats exhibited signs of activation of sympathetic nervous system, while NaHS-treated rats showed mobilization of all parts of regulatory systems with predominant activation of the parasympathetic nervous system (PSNS). Overall, these results indicate that NaHS is involved in cardiac control and decreases sensitivity to low doses of radiation.
Conclusion: The gaseous messenger H2S under conditions of radiation modulates adaptive processes, acting as a regulator for imbalance of autonomic nervous system and may serve as a novel cardioprotective agent for ANS imbalance.
Ključne riječi
hydrogen sulfide H2S; sodium bisulfide; radiation effects; autonomic nervous system (ANS); cardiovascular system (CVS); heart rate control
Hrčak ID:
213820
URI
Datum izdavanja:
27.11.2018.
Posjeta: 576 *