Pregledni rad
https://doi.org/10.17113/ftb.56.04.18.5805
The Role of Vitamin D in Inflammatory Bowel Disease–Assessing Therapeutic and Preventive Potential of Supplementation and Food Fortification
Dunja Leskovar
; University of Zagreb School of Medicine, Šalata 3, 10 000 Zagreb, Croatia
Tomislav Meštrović
; Polyclinic “Dr. Zora Profozić”, Bosutska 19, 10 000 Zagreb, Croatia
Anja Barešić
; MRC London Institute of Medical Sciences, Du Cane Rd, London W12 0NN, United Kingdom
Ivana Kraljević
; University Hospital Centre, Kišpatićeva 12, 10 000 Zagreb, Croatia
Marina Panek
; University of Zagreb School of Medicine, Šalata 3, 10 000 Zagreb, Croatia
Hana Čipčić Paljetak
; University of Zagreb School of Medicine, Šalata 3, 10 000 Zagreb, Croatia
Mihaela Perić
; University of Zagreb School of Medicine, Šalata 3, 10 000 Zagreb, Croatia
Mario Matijašić
; University of Zagreb School of Medicine, Šalata 3, 10 000 Zagreb, Croatia
Dunja Rogić
; University Hospital Centre, Kišpatićeva 12, 10 000 Zagreb, Croatia
Ana Barišić
; University Hospital Centre, Kišpatićeva 12, 10 000 Zagreb, Croatia
Dina Ljubas Kelečić
; University Hospital Centre, Kišpatićeva 12, 10 000 Zagreb, Croatia
Darija Vranešić Bender
; University Hospital Centre, Kišpatićeva 12, 10 000 Zagreb, Croatia
Željko Krznarić
; University Hospital Centre, Kišpatićeva 12, 10 000 Zagreb, Croatia
Donatella Verbanac
; University of Zagreb, Faculty of Pharmacy and Biochemistry, A. Kovačića 1, 10 000 Zagreb, Croatia
Sažetak
Inflammatory bowel diseases are a group of chronic inflammatory conditions that affect gastrointestinal tract due to inapt and continuous immune activation in response to a myriad of predisposing factors (most notably genetics, environmental impact and gut microbiota composition). It has been shown that vitamin D status can also play a role in the disease pathogenesis, as its deficiency is commonly observed in two major forms of inflammatory bowel diseases – Crohn’s disease and ulcerative colitis. Mounting evidence supports the concept of intricate relationship between gut dysbiosis and vitamin D metabolism, while suboptimal levels of this vitamin have been linked to increased clinical disease relapse rates, inadequate response to drugs, as well as decreased quality of life in patients with Crohn’s disease and ulcerative colitis. Consequently, the pertinent question is whether increased vitamin D supplementation and (on a population level) food fortification may bring significant benefit to the affected individuals. In this short review we discuss the synthesis, functions, status and food sources of vitamin D, appraise biotechnological facets of vitamin D status analysis and food fortification, and concentrate on novel developments in the field that describe its influence on intestinal microbiota and inflammatory bowel disease.
Ključne riječi
inflammatory bowel diseases; Crohn’s disease; ulcerative colitis; vitamin D; gut microbiota; dysbiosis
Hrčak ID:
214924
URI
Datum izdavanja:
31.12.2018.
Posjeta: 2.310 *