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Necrolytic migratory erythema: complete healing after surgical removal of pancreatic carcinoma

Marija V'lckova Laskoska ; University of Skopje, Skopje, R.of Macedonia
Margareta Balabanova-Stefanova ; University of Skopje, Skopje, R.of Macedonia
Irina Arsovska-Bezhoska ; University of Skopje, Skopje, R.of Macedonia
Nina Caca Biljanovska ; University of Skopje, Skopje, R.of Macedonia
Dimitri Laskoski ; Univesity Of Skopje, Skopje, R.of Macedonia


Puni tekst: engleski PDF 146 Kb

str. 329-329

preuzimanja: 314

citiraj


Sažetak

Necrolytic migratory erythema is considered an obligatory cutaneous paraneoplastic sign associated with glucagonoma. Glucagonoma syndrome is defined by the presence of an alpha-cell secreting tumor of the pancreas, elevated levels of glucagon, and a characteristic rash called necrolytic migratory erythema. Although necrolytic migratory erythema is a specific finding in glucagonoma syndrome, it may occur in other settings, unassociated with an alpha-cell pancreatic tumor (pseudoglucagonoma syndrome). The rarity of glucagonoma imposes a challenge, with most patients being diagnosed after a long period of treatment for their skin rash. The main prognostic sign of glucagonoma are the subsequent metastases that come late in the course of the disease. Herein, we present a 55-year-old female patient with a 5-year history of unrecognized cutaneous and systemic manifestations of glucagonoma syndrome. Based on the investigations, the diagnosis of glucagonoma syndrome without metastases was established. After surgical removal of pancreatic carcinoma/glucagonoma, complete healing and a long disease-free period was achieved. Appropriate awareness of the characteristics of necrolytic migratory erythema in physicians/dermatologists often leads to an early diagnosis of glucagonoma syndrome and enhances the chances of a favorable outcome.

healing and long disease-free period was achieved. The awareness of physicians/dermatologists of the characteristic necrolytic migratory erythema, often leads to an early diagnosis of glucagonoma syndrome and enhance the chances of a favorable outcome.

Ključne riječi

Hrčak ID:

215854

URI

https://hrcak.srce.hr/215854

Datum izdavanja:

17.1.2019.

Posjeta: 684 *