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https://doi.org/10.5562/cca3429

Synthesis and Biological Evaluation of Novel Gallic Acid Analogues as Potential Antimicrobial and Antioxidant Agents

Lubna Sherin ; Department of Chemistry, COMSATS University Islamabad, Lahore, Defence Road, Off Raiwind Road, Lahore, 54000, Pakistan
Shahida Shujaat ; Department of Chemistry, Lahore College for Women University, Lahore, 54000, Pakistan
Ayesha Sohail ; Department of Mathematics, COMSATS University Islamabad, Lahore, 54000, Pakistan
Fatima Arif ; Department of Mathematics, COMSATS University Islamabad, Lahore, 54000, Pakistan

Puni tekst: engleski, pdf (4 MB) str. 551-565 preuzimanja: 221* citiraj
APA 6th Edition
Sherin, L., Shujaat, S., Sohail, A. i Arif, F. (2018). Synthesis and Biological Evaluation of Novel Gallic Acid Analogues as Potential Antimicrobial and Antioxidant Agents. Croatica Chemica Acta, 91 (4), 551-565. https://doi.org/10.5562/cca3429
MLA 8th Edition
Sherin, Lubna, et al. "Synthesis and Biological Evaluation of Novel Gallic Acid Analogues as Potential Antimicrobial and Antioxidant Agents." Croatica Chemica Acta, vol. 91, br. 4, 2018, str. 551-565. https://doi.org/10.5562/cca3429. Citirano 09.12.2019.
Chicago 17th Edition
Sherin, Lubna, Shahida Shujaat, Ayesha Sohail i Fatima Arif. "Synthesis and Biological Evaluation of Novel Gallic Acid Analogues as Potential Antimicrobial and Antioxidant Agents." Croatica Chemica Acta 91, br. 4 (2018): 551-565. https://doi.org/10.5562/cca3429
Harvard
Sherin, L., et al. (2018). 'Synthesis and Biological Evaluation of Novel Gallic Acid Analogues as Potential Antimicrobial and Antioxidant Agents', Croatica Chemica Acta, 91(4), str. 551-565. https://doi.org/10.5562/cca3429
Vancouver
Sherin L, Shujaat S, Sohail A, Arif F. Synthesis and Biological Evaluation of Novel Gallic Acid Analogues as Potential Antimicrobial and Antioxidant Agents. Croatica Chemica Acta [Internet]. 2018 [pristupljeno 09.12.2019.];91(4):551-565. https://doi.org/10.5562/cca3429
IEEE
L. Sherin, S. Shujaat, A. Sohail i F. Arif, "Synthesis and Biological Evaluation of Novel Gallic Acid Analogues as Potential Antimicrobial and Antioxidant Agents", Croatica Chemica Acta, vol.91, br. 4, str. 551-565, 2018. [Online]. https://doi.org/10.5562/cca3429

Sažetak
A series of fifteen novel gallic acid esters (7a-o) was synthesized and structure was confirmed by spectral data. Antibiotic power of compounds was assessed against a panel of ten microbes while antioxidant activity was gauged by employing DPPH, ABTS and antilipid peroxidation assays. It was found that in comparison to lead, many of the synthesized derivatives implied much improved broad spectrum antimicrobial effect. Most effective compound found was 7c specifically against resistant gram-negative strains such as P. aeruginosa, E. coli and E. aerogenes. Potent antioxidant capacity was exhibited by7a and 7d in electron transfer assays while 7j and 7c provided maximum shielding against lipid peroxidation. Structure-activity analysis revealed that analogues with electron -withdrawing substituent particularly chloro group stand out as much better antibiotic agent. This study suggests that halogenated gallic acid analogues might be promising pharmacological candidates in view of further drug development.

Creative Commons License This work is licensed under a Creative Commons Attribution 4.0 International License.

Ključne riječi
antimicrobial activity; antioxidant activity; electron-withdrawing substituent; gallic acid esters; structure-activity relationship

Hrčak ID: 216130

URI
https://hrcak.srce.hr/216130

Posjeta: 331 *