Acta Pharmaceutica, Vol. 69 No. 3, 2019.
Pregledni rad
https://doi.org/10.2478/acph-2019-0023
An overview of structurally diversified anticonvulsant agents
FAISAL AL-OTAIBI
; Department of Clinical Pharmacy, College of Pharmacy, Shaqra University, Al-dawadmi, P. O. BOX 33, Saudi Arabia
Sažetak
There are several limited approaches to treat epilepsy in hospitals, for example, using medicines, surgery, electrical stimulation and dietary interventions. Despite the availability of all these new and old approaches, seizure is particularly difficult to manage. The quest for new antiepileptic molecules with more specificity and less CNS toxicity continues for medicinal chemists until a new and ideal drug arrives. This review covers new antiseizure molecules of different chemical classes, the exact mode of action of which is still unidentified. Newer agents include sulfonamides, thiadiazoles, semi- and thiosemicarbazones, pyrrolidine-2,5-diones, imidazoles, benzothiazoles and amino acid derivatives. These new chemical entities can be useful for the design and development of forthcoming antiseizure agents.
Ključne riječi
antiepileptic agents; sulfonamides; imidazoles; thiadiazoles; benzothiazoles and amino acid derivatives
Hrčak ID:
216136
URI
Datum izdavanja:
30.9.2019.
Posjeta: 1.187 *