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URINE CONCENTRATIONS OF HIGH-SENSITIVITY CARDIAC TROPONIN I IN HEALTHY ADULTS – PRELIMINARY REFERENCE INTERVALS

PETRA PERVAN ; Zagreb-Center Health Centre, Zagreb, Croatia
TOMO SVAGUŠA   ORCID icon orcid.org/0000-0002-2036-1239 ; University of Zagreb, School of Medicine, Dubrava University Hospital, Department of Internal Medicine, Zagreb, Croatia
INGRID PRKAČIN   ORCID icon orcid.org/0000-0002-5830-7131 ; University of Zagreb, School of Medicine, Merkur University Hospital, Department of Internal Medicine, Zagreb, Croatia
JURICA VUKOVIĆ ; Merkur University Hospital, Department of Urology, Croatia
ANDREA RADELJAK ; Merkur University Hospital, Department of Medical Biochemistry and Laboratory Medicine, Reference Center for the Production of Reference Values in the Field of General Medical Biochemistry of the Ministry of Health of the Republic of Croatia, Zagreb, Croa
SONJA PERKOV ; Merkur University Hospital, Department of Medical Biochemistry and Laboratory Medicine, Reference Center for the Production of Reference Values in the Field of General Medical Biochemistry of the Ministry of Health of the Republic of Croatia, Zagreb, Croa

Puni tekst: engleski, pdf (90 KB) str. 461-465 preuzimanja: 46* citiraj
APA 6th Edition
PERVAN, P., SVAGUŠA, T., PRKAČIN, I., VUKOVIĆ, J., RADELJAK, A. i PERKOV, S. (2018). URINE CONCENTRATIONS OF HIGH-SENSITIVITY CARDIAC TROPONIN I IN HEALTHY ADULTS – PRELIMINARY REFERENCE INTERVALS. Acta medica Croatica, 72 (4), 461-465. Preuzeto s https://hrcak.srce.hr/216412
MLA 8th Edition
PERVAN, PETRA, et al. "URINE CONCENTRATIONS OF HIGH-SENSITIVITY CARDIAC TROPONIN I IN HEALTHY ADULTS – PRELIMINARY REFERENCE INTERVALS." Acta medica Croatica, vol. 72, br. 4, 2018, str. 461-465. https://hrcak.srce.hr/216412. Citirano 14.10.2019.
Chicago 17th Edition
PERVAN, PETRA, TOMO SVAGUŠA, INGRID PRKAČIN, JURICA VUKOVIĆ, ANDREA RADELJAK i SONJA PERKOV. "URINE CONCENTRATIONS OF HIGH-SENSITIVITY CARDIAC TROPONIN I IN HEALTHY ADULTS – PRELIMINARY REFERENCE INTERVALS." Acta medica Croatica 72, br. 4 (2018): 461-465. https://hrcak.srce.hr/216412
Harvard
PERVAN, P., et al. (2018). 'URINE CONCENTRATIONS OF HIGH-SENSITIVITY CARDIAC TROPONIN I IN HEALTHY ADULTS – PRELIMINARY REFERENCE INTERVALS', Acta medica Croatica, 72(4), str. 461-465. Preuzeto s: https://hrcak.srce.hr/216412 (Datum pristupa: 14.10.2019.)
Vancouver
PERVAN P, SVAGUŠA T, PRKAČIN I, VUKOVIĆ J, RADELJAK A, PERKOV S. URINE CONCENTRATIONS OF HIGH-SENSITIVITY CARDIAC TROPONIN I IN HEALTHY ADULTS – PRELIMINARY REFERENCE INTERVALS. Acta medica Croatica [Internet]. 2018 [pristupljeno 14.10.2019.];72(4):461-465. Dostupno na: https://hrcak.srce.hr/216412
IEEE
P. PERVAN, T. SVAGUŠA, I. PRKAČIN, J. VUKOVIĆ, A. RADELJAK i S. PERKOV, "URINE CONCENTRATIONS OF HIGH-SENSITIVITY CARDIAC TROPONIN I IN HEALTHY ADULTS – PRELIMINARY REFERENCE INTERVALS", Acta medica Croatica, vol.72, br. 4, str. 461-465, 2018. [Online]. Dostupno na: https://hrcak.srce.hr/216412. [Citirano: 14.10.2019.]

Sažetak
Recent studies have shown the presence of troponin molecules in urine, with kidneys considered the main organs of elimination. Availability of the new generation of high-sensitivity assays has enabled detection of low concentrations of circulating cardiac troponins, but the high-sensitivity troponin assays are not designed for analysis of urine specimens. The aim of this study was to establish preliminary reference intervals for the high-sensitivity cardiac troponin I (hs-cTnI) concentrations in urine of healthy adults in Croatia. A total of 60 reference persons were selected (30 males and 30 females) and the concentrations of hs-cTnI in random urine samples were determined on the Abbott Architect i1000SR (Abbott Laboratories) analytical system with chemiluminescent immunochemical method on microparticles (CMIA, ARCHITECT STAT High Sensitive Troponin-I), accredited according to the HR EN ISO 15189:2012 standard (Medical laboratorieds – requirements for quality and competence. Geneva, International Organization for Standardization, 2012). We determined the limit of detection, total laboratory precision, expanded measurement uncertainty and preliminary estimates of the gender-specifi c 99th percentile of the upper reference limit (URL) using nonparametric analysis (methods). The male and female 99th percentile cut-off values were 39.3 and 35.2 pg/mL, respectively. The results of this pilot study suggest that troponin I is removed from the blood by the kidneys and can be determined in the urine with CMIA, ARCHITECT STAT High Sensitive Troponin-I assays. Further research is focused on detailed studies of biochemistry and determination of troponin I in the urine as a new biological marker.

Ključne riječi
troponin I; determination in urine

Hrčak ID: 216412

URI
https://hrcak.srce.hr/216412

[hrvatski]

Posjeta: 133 *