Skoči na glavni sadržaj

Izvorni znanstveni članak

https://doi.org/10.15255/CABEQ.2018.1454

Physicochemical Properties, Cytotoxicity, and Antioxidative Activity of Natural Deep Eutectic Solvents Containing Organic Acid

A. Mitar ; University of Zagreb, Faculty of Chemical Engineering and Technology, Marulićev trg 20, 10000 Zagreb, Croatia
M. Panić ; niversity of Zagreb, Faculty of Food Technology and Biotechnology, Pierottijeva 6, 10000 Zagreb, Croatia
J. Prlić Kardum ; University of Zagreb, Faculty of Chemical Engineering and Technology, Marulićev trg 20, 10000 Zagreb, Croatia
J. Halambek ; Karlovac University of Applied Sciences, Trg J.J. Strossmayera 9, 47 000 Karlovac, Croatia
A. Sander ; University of Zagreb, Faculty of Chemical Engineering and Technology, Marulićev trg 20, 10000 Zagreb, Croatia
K. Zagajski Kučan ; University of Zagreb, Faculty of Chemical Engineering and Technology, Marulićev trg 20, 10000 Zagreb, Croatia
I. Radojčić Redovniković ; niversity of Zagreb, Faculty of Food Technology and Biotechnology, Pierottijeva 6, 10000 Zagreb, Croatia
K. Radošević ; niversity of Zagreb, Faculty of Food Technology and Biotechnology, Pierottijeva 6, 10000 Zagreb, Croatia


Puni tekst: engleski pdf 2.367 Kb

str. 1-18

preuzimanja: 1.054

citiraj


Sažetak

Natural deep eutectic solvents (NADES) may be considered ‘designer solvents’ due to their numerous structural variations and the possibility of tailoring their physicochemical properties. Prior to their industrial application, characterization of NADES is essential, including determination of their physicochemical properties, cytotoxicity, and antioxidative activity. The most important physicochemical properties of eight prepared NADES (choline chloride:malic acid, proline:malic acid, choline chloride:proline:malic acid, betaine:malic acid, malic acid:glucose, malic acid:glucose:glycerol, choline chloride:citric acid, and betaine:citric acid) were measured as functions of temperature and
water content. In general, the structure of prepared NADES greatly influences their physical properties, which could be successfully modified and adjusted by addition of water. All tested NADES were absolutely benign and noncorrosive for investigated steel
X6CrNiTi18-10. Furthermore, cytotoxicity of prepared solvents was assessed toward three human cell lines (HEK-293T, HeLa, and MCF-7 cells), and antioxidative activity was measured by the Oxygen Radical Absorbance Capacity (ORAC) method. With regard to cell viability, all tested NADES containing carboxylic acid could be classified as practically harmless and considered environmentally safe. The ORAC values indicated that the tested NADES displayed antioxidative activity.







This work is licensed under a Creative Commons Attribution 4.0 International License.

Ključne riječi

antioxidative activity; corrosion rate; cytotoxicity; natural deep eutectic solvents; physicochemical characterization

Hrčak ID:

218879

URI

https://hrcak.srce.hr/218879

Datum izdavanja:

10.4.2019.

Posjeta: 2.573 *