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https://doi.org/10.22514/SV151.042019.2

Diagnostic markers of serious bacterial infections in infants aged 29 to 90 days

SANGSOO HAN
SUNGWOO CHOI
YOUNG SOON CHO   ORCID icon orcid.org/0000-0002-6843-9517 ; Department of Emergency Medicine, Soonchunhyang University Bucheon Hospital, Soonchunhyang University College of Medicine, 170 Jomaru-ro, Bucheon 14584, Republic of Korea

Puni tekst: engleski, pdf (223 KB) str. 22-26 preuzimanja: 59* citiraj
APA 6th Edition
HAN, S., CHOI, S. i CHO, Y.S. (2019). Diagnostic markers of serious bacterial infections in infants aged 29 to 90 days. Signa vitae, 15 (1), 22-26. https://doi.org/10.22514/SV151.042019.2
MLA 8th Edition
HAN, SANGSOO, et al. "Diagnostic markers of serious bacterial infections in infants aged 29 to 90 days." Signa vitae, vol. 15, br. 1, 2019, str. 22-26. https://doi.org/10.22514/SV151.042019.2. Citirano 21.11.2019.
Chicago 17th Edition
HAN, SANGSOO, SUNGWOO CHOI i YOUNG SOON CHO. "Diagnostic markers of serious bacterial infections in infants aged 29 to 90 days." Signa vitae 15, br. 1 (2019): 22-26. https://doi.org/10.22514/SV151.042019.2
Harvard
HAN, S., CHOI, S., i CHO, Y.S. (2019). 'Diagnostic markers of serious bacterial infections in infants aged 29 to 90 days', Signa vitae, 15(1), str. 22-26. https://doi.org/10.22514/SV151.042019.2
Vancouver
HAN S, CHOI S, CHO YS. Diagnostic markers of serious bacterial infections in infants aged 29 to 90 days. Signa vitae [Internet]. 2019 [pristupljeno 21.11.2019.];15(1):22-26. https://doi.org/10.22514/SV151.042019.2
IEEE
S. HAN, S. CHOI i Y.S. CHO, "Diagnostic markers of serious bacterial infections in infants aged 29 to 90 days", Signa vitae, vol.15, br. 1, str. 22-26, 2019. [Online]. https://doi.org/10.22514/SV151.042019.2

Sažetak
Objectives: The diagnosis of serious bacterial infection (SBI) is difficult due to a lack of clinical evidence. The purpose of this study was to determine which inflammatory markers can be used to detect SBI in febrile infants.

Methods: This retrospective cohort study included infants aged 29 to 90 days who visited a tertiary hospital emergency department in Korea between July 2016 and June 2018. The diagnostic characteristics of the neutrophil-to-lymphocyte ratio (NLR), procalcitonin (PCT), C-reactive protein (CRP), white blood cell (WBC) count, and absolute neutrophil cell (ANC) count for detecting SBI were described. Their cutoff values were calculated based on receiver operating characteristic (ROC) curve analysis.

Results: Among 528 infants, 199 were finally enrolled. SBI was detected in 68 (34.2%) of these infants. The median values of all investigated diagnostic markers were significantly higher in infants with SBI than the values in those without: WBC (12.72 vs. 9.91 k/μL), ANC (6.28 vs. 3.14 k/μL), CRP (26.6 vs. 2.8 mg/L), NLR (1.29 vs. 0.78), and PCT (0.5 vs. 0 ng/mL). The areas under the ROC curves for discriminating SBI were: 0.705 (95% confidence interval [CI], 0.629-0.781), 0.793 (95% CI, 0.731-0.856), 0.832 (95% CI, 0.775-0.889), 0.722 (95% CI, 0.651-0.792), and 0.695 (95% CI, 0.611-0.780) for WBC, ANC, CRP, NLR, and PCT, respectively. Using a cutoff value of 0.67 for NLR, the negative predictive value was 90.8% for identifying SBI.

Conclusions: CRP was the best single discriminatory marker of SBI, while NLR was the best parameter for considering discharge.

Ključne riječi
bacterial infection; urinary tract infection; clinical marker; discharge planning

Hrčak ID: 219760

URI
https://hrcak.srce.hr/219760

Posjeta: 110 *