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https://doi.org/10.5599/jese.652

Electrochemical reduction of artemisinin: Chromatographic identification of bulk electrolysis products

Faraja Obwayo ; Department of Chemistry and Biochemistry, Rowan University, Glassboro, NJ 08028, USA
Zahilis Mazzochette ; Department of Chemistry and Biochemistry, Rowan University, Glassboro, NJ 08028, USA
Amos Mugweru ; Department of Chemistry and Biochemistry, Rowan University, Glassboro, NJ 08028, USA

Puni tekst: engleski, pdf (2 MB) str. 165-174 preuzimanja: 234* citiraj
APA 6th Edition
Obwayo, F., Mazzochette, Z. i Mugweru, A. (2019). Electrochemical reduction of artemisinin: Chromatographic identification of bulk electrolysis products. Journal of Electrochemical Science and Engineering, 9 (3), 165-174. https://doi.org/10.5599/jese.652
MLA 8th Edition
Obwayo, Faraja, et al. "Electrochemical reduction of artemisinin: Chromatographic identification of bulk electrolysis products." Journal of Electrochemical Science and Engineering, vol. 9, br. 3, 2019, str. 165-174. https://doi.org/10.5599/jese.652. Citirano 26.07.2021.
Chicago 17th Edition
Obwayo, Faraja, Zahilis Mazzochette i Amos Mugweru. "Electrochemical reduction of artemisinin: Chromatographic identification of bulk electrolysis products." Journal of Electrochemical Science and Engineering 9, br. 3 (2019): 165-174. https://doi.org/10.5599/jese.652
Harvard
Obwayo, F., Mazzochette, Z., i Mugweru, A. (2019). 'Electrochemical reduction of artemisinin: Chromatographic identification of bulk electrolysis products', Journal of Electrochemical Science and Engineering, 9(3), str. 165-174. https://doi.org/10.5599/jese.652
Vancouver
Obwayo F, Mazzochette Z, Mugweru A. Electrochemical reduction of artemisinin: Chromatographic identification of bulk electrolysis products. Journal of Electrochemical Science and Engineering [Internet]. 2019 [pristupljeno 26.07.2021.];9(3):165-174. https://doi.org/10.5599/jese.652
IEEE
F. Obwayo, Z. Mazzochette i A. Mugweru, "Electrochemical reduction of artemisinin: Chromatographic identification of bulk electrolysis products", Journal of Electrochemical Science and Engineering, vol.9, br. 3, str. 165-174, 2019. [Online]. https://doi.org/10.5599/jese.652

Sažetak
Artemisinin is a naturally occurring sesquiterpene lactone with an endo-peroxide bond. This drug is used for treatment of many diseases including malaria. The reduction of this molecule on an electrode surface was carried out by cyclic voltammetry as well as amperometry. Cyclic voltammetry of artemisinin generated one prominent peak wave at -1.0 V and another, smaller one at -0.3 V vs Ag/AgCl reference electrode. The bulk electrolysis of artemisinin on a carbon electrode generated two other irreversible peak waves at around -0.7 and -0.1 V. The concentration of the products was dependent on the time of electrolysis. LC-MS was used to determine the bulk electrolysis products of artemisinin. Initially dihydroartemisinin was generated as the main reduction product. Other reduction products were formed after further reduction of dyhidroartemisinin.

Ključne riječi
Cyclic voltammetry; dyhidroartemisinin; electrochemical reduction; bulk electrolysis; LC-MS

Hrčak ID: 219924

URI
https://hrcak.srce.hr/219924

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